3er3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:3er3.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:3er3.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_3er3| PDB=3er3 | SCENE= }}
{{STRUCTURE_3er3| PDB=3er3 | SCENE= }}
-
'''THE ACTIVE SITE OF ASPARTIC PROTEINASES'''
+
===THE ACTIVE SITE OF ASPARTIC PROTEINASES===
-
==Overview==
+
<!--
-
The active site of the aspartic proteinase, endothiapepsin, has been defined by X-ray analysis and restrained least-squares refinement at 2.1 A resolution with a crystallographic agreement value of 0.16. The environments of the two catalytically important aspartyl groups are remarkably similar and the contributions of the NH2- and COOH-terminal domains to the catalytic centre are related by a local 2-fold axis. The carboxylates of the aspartyls share a hydrogen bond and have equivalent contacts to a bound water molecule or hydroxonium ion lying on the local diad. The main chains around 32 and 215 are connected by a novel interaction involving diad-related threonines. It is suggested that the two pKa values of the active site aspartyls arise from a structure not unlike that in maleic acid with a hydrogen-bonded intermediate species and a dicarboxylate characterised by electrostatic repulsions between the two negatively charged groups.
+
The line below this paragraph, {{ABSTRACT_PUBMED_6381096}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 6381096 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_6381096}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Hoover, D.]]
[[Category: Hoover, D.]]
[[Category: Veerapandian, B.]]
[[Category: Veerapandian, B.]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:00:49 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:32:05 2008''

Revision as of 10:32, 27 July 2008

Image:3er3.png

Template:STRUCTURE 3er3

THE ACTIVE SITE OF ASPARTIC PROTEINASES

Template:ABSTRACT PUBMED 6381096

About this Structure

3ER3 is a Single protein structure. Full crystallographic information is available from OCA.

Reference

The active site of aspartic proteinases., Pearl L, Blundell T, FEBS Lett. 1984 Aug 20;174(1):96-101. PMID:6381096

Page seeded by OCA on Sun Jul 27 13:32:05 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3er3"
Personal tools