3hck

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[[Image:3hck.gif|left|200px]]
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{{STRUCTURE_3hck| PDB=3hck | SCENE= }}
{{STRUCTURE_3hck| PDB=3hck | SCENE= }}
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'''NMR ENSEMBLE OF THE UNCOMPLEXED HUMAN HCK SH2 DOMAIN, 20 STRUCTURES'''
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===NMR ENSEMBLE OF THE UNCOMPLEXED HUMAN HCK SH2 DOMAIN, 20 STRUCTURES===
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==Overview==
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The hematopoietic cellular kinase (Hck) is a member of the Src family of non-receptor protein-tyrosine kinases and participates in signal transduction events regulating the growth, differentiation and function of phagocytes. The secondary structure of the SH2 domain for Hck was determined for a 13C/15N-enriched sample using multi-dimensional NMR spectroscopy. The secondary structure for the domain was determined from chemical shift indices [1H alpha, 13C alpha and 13C'], sequential NOEs [d(alphaN)(i, i+1) and d(NN)(i, i+1)], and 3J(alphaN) scalar coupling constants. The Hck SH2 domain consists of two alpha-helices and seven beta-strands. Complementary strands of beta-sheets were identified from long-range NOEs using a novel 3D, 13C/15N-edited HMQC-NOESY-(HCACO)NH experiment that correlated 1H alpha resonances between beta-strands. The secondary structure for Hck SH2 is similar to that predicted from the sequence alignment of the Src-family protein tyrosine kinases.
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(as it appears on PubMed at http://www.pubmed.gov), where 9109402 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9109402}}
==About this Structure==
==About this Structure==
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3HCK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HCK OCA].
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3HCK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HCK OCA].
==Reference==
==Reference==
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Tyrosine kinase]]
[[Category: Tyrosine kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:03:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 12:48:30 2008''

Revision as of 09:48, 3 July 2008

Image:3hck.png

Template:STRUCTURE 3hck

NMR ENSEMBLE OF THE UNCOMPLEXED HUMAN HCK SH2 DOMAIN, 20 STRUCTURES

Template:ABSTRACT PUBMED 9109402

About this Structure

3HCK is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Sequential assignment and secondary structure determination for the Src homology 2 domain of hematopoietic cellular kinase., Zhang W, Smithgall TE, Gmeiner WH, FEBS Lett. 1997 Apr 7;406(1-2):131-5. PMID:9109402

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