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3phm

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[[Image:3phm.gif|left|200px]]
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{{Seed}}
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[[Image:3phm.png|left|200px]]
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{{STRUCTURE_3phm| PDB=3phm | SCENE= }}
{{STRUCTURE_3phm| PDB=3phm | SCENE= }}
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'''REDUCED (CU+) PEPTIDYLGLYCINE ALPHA-HYDROXYLATING MONOOXYGENASE (PHM)'''
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===REDUCED (CU+) PEPTIDYLGLYCINE ALPHA-HYDROXYLATING MONOOXYGENASE (PHM)===
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==Overview==
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Peptide amidation is a ubiquitous posttranslational modification of bioactive peptides. Peptidylglycine alpha-hydroxylating monooxygenase (PHM; EC 1.14.17.3), the enzyme that catalyzes the first step of this reaction, is composed of two domains, each of which binds one copper atom. The coppers are held 11 A apart on either side of a solvent-filled interdomain cleft, and the PHM reaction requires electron transfer between these sites. A plausible mechanism for electron transfer might involve interdomain motion to decrease the distance between the copper atoms. Our experiments show that PHM catalytic core (PHMcc) is enzymatically active in the crystal phase, where interdomain motion is not possible. Instead, structures of two states relevant to catalysis indicate that water, substrate and active site residues may provide an electron transfer pathway that exists only during the PHM catalytic cycle.
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The line below this paragraph, {{ABSTRACT_PUBMED_10504734}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10504734 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10504734}}
==About this Structure==
==About this Structure==
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[[Category: Monooxygenase]]
[[Category: Monooxygenase]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:10:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:02:03 2008''

Revision as of 10:02, 3 July 2008

Image:3phm.png

Template:STRUCTURE 3phm

REDUCED (CU+) PEPTIDYLGLYCINE ALPHA-HYDROXYLATING MONOOXYGENASE (PHM)

Template:ABSTRACT PUBMED 10504734

About this Structure

3PHM is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Substrate-mediated electron transfer in peptidylglycine alpha-hydroxylating monooxygenase., Prigge ST, Kolhekar AS, Eipper BA, Mains RE, Amzel LM, Nat Struct Biol. 1999 Oct;6(10):976-83. PMID:10504734

Page seeded by OCA on Thu Jul 3 13:02:03 2008

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