413d

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{{STRUCTURE_413d| PDB=413d | SCENE= }}
{{STRUCTURE_413d| PDB=413d | SCENE= }}
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'''A'-FORM RNA DOUBLE HELIX IN THE SINGLE CRYSTAL STRUCTURE OF R(UGAGCUUCGGCUC)'''
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===A'-FORM RNA DOUBLE HELIX IN THE SINGLE CRYSTAL STRUCTURE OF R(UGAGCUUCGGCUC)===
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==Overview==
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Here we demonstrate the presence of the A'-RNA conformation using the single crystal structure of a tridecamer: r(UGAGCUUCGGCUC). The average A'-RNA conformation deduced from X-ray fiber diffraction data had only been available previously, but now the presence of the A'-RNA conformation has been found in a single crystal structure for the first time. Statistical analysis showed that the A'-RNA conformation is distinguishable from the A-RNA conformation in a plot of the major groove width against the base pair inclination angle. The major groove of the A'-RNA conformation is wide enough to accommodate a protein or peptide while that of the A-RNA conformation is too narrow to do so. The presence of the A'-RNA conformation is significant for protein-RNA interaction.
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(as it appears on PubMed at http://www.pubmed.gov), where 9927725 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9927725}}
==About this Structure==
==About this Structure==
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[[Category: A'-rna]]
[[Category: A'-rna]]
[[Category: Double helix]]
[[Category: Double helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:16:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:16:10 2008''

Revision as of 10:16, 3 July 2008

Image:413d.png

Template:STRUCTURE 413d

A'-FORM RNA DOUBLE HELIX IN THE SINGLE CRYSTAL STRUCTURE OF R(UGAGCUUCGGCUC)

Template:ABSTRACT PUBMED 9927725

About this Structure

This structure supersedes the now removed PDB entry 373d. Full crystallographic information is available from OCA.

Reference

A'-form RNA double helix in the single crystal structure of r(UGAGCUUCGGCUC)., Tanaka Y, Fujii S, Hiroaki H, Sakata T, Tanaka T, Uesugi S, Tomita K, Kyogoku Y, Nucleic Acids Res. 1999 Feb 15;27(4):949-55. PMID:9927725

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