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430d

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{{STRUCTURE_430d| PDB=430d | SCENE= }}
{{STRUCTURE_430d| PDB=430d | SCENE= }}
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'''STRUCTURE OF SARCIN/RICIN LOOP FROM RAT 28S RRNA'''
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===STRUCTURE OF SARCIN/RICIN LOOP FROM RAT 28S RRNA===
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==Overview==
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The structure of a 29-nucleotide RNA containing the sarcin/ricin loop (SRL) of rat 28 S rRNA has been determined at 2.1 A resolution. Recognition of the SRL by elongation factors and by the ribotoxins, sarcin and ricin, requires a nearly universal dodecamer sequence that folds into a G-bulged cross-strand A stack and a GAGA tetraloop. The juxtaposition of these two motifs forms a distorted hairpin structure that allows direct recognition of bases in both grooves as well as recognition of nonhelical backbone geometry and two 5'-unstacked purines. Comparisons with other RNA crystal structures establish the cross-strand A stack and the GNRA tetraloop as defined and modular RNA structural elements. The conserved region at the top is connected to the base of the domain by a region presumed to be flexible because of the sparsity of stabilizing contacts. Although the conformation of the SRL RNA previously determined by NMR spectroscopy is similar to the structure determined by x-ray crystallography, significant differences are observed in the "flexible" region and to a lesser extent in the G-bulged cross-strand A stack.
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The line below this paragraph, {{ABSTRACT_PUBMED_9811818}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9811818 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9811818}}
==About this Structure==
==About this Structure==
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[[Category: Tetraloop mismatched]]
[[Category: Tetraloop mismatched]]
[[Category: U-rna]]
[[Category: U-rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:17:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:18:30 2008''

Revision as of 10:18, 3 July 2008

Image:430d.png

Template:STRUCTURE 430d

STRUCTURE OF SARCIN/RICIN LOOP FROM RAT 28S RRNA

Template:ABSTRACT PUBMED 9811818

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of the ribosomal RNA domain essential for binding elongation factors., Correll CC, Munishkin A, Chan YL, Ren Z, Wool IG, Steitz TA, Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13436-41. PMID:9811818

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