4aig

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{{STRUCTURE_4aig| PDB=4aig | SCENE= }}
{{STRUCTURE_4aig| PDB=4aig | SCENE= }}
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'''ADAMALYSIN II WITH PHOSPHONATE INHIBITOR'''
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===ADAMALYSIN II WITH PHOSPHONATE INHIBITOR===
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==Overview==
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The search of reprolysin inhibitors offers the possibility of intervention against both matrixins and ADAMs. Here we report the crystal structure of the complex between adamalysin II, a member of the reprolysin family, and a phosphonate inhibitor modeled on an endogenous venom tripeptide. The inhibitor occupies the primed region of the cleavage site adopting a retro-binding mode. The phosphonate group ligates the zinc ion in an asymmetric bidentate mode and the adjacent Trp indole system partly fills the primary specificity subsite S1'. An adamalysin-based model of tumor necrosis factor-alpha-converting enzyme (TACE) reveals a smaller S1' pocket for this enzyme.
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(as it appears on PubMed at http://www.pubmed.gov), where 9428736 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9428736}}
==About this Structure==
==About this Structure==
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[[Category: Snake venom metalloendopeptidase]]
[[Category: Snake venom metalloendopeptidase]]
[[Category: Zinc protease]]
[[Category: Zinc protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:20:29 2008''
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Revision as of 10:27, 3 July 2008

Image:4aig.png

Template:STRUCTURE 4aig

ADAMALYSIN II WITH PHOSPHONATE INHIBITOR

Template:ABSTRACT PUBMED 9428736

About this Structure

4AIG is a Single protein structure of sequence from Crotalus adamanteus. Full crystallographic information is available from OCA.

Reference

2 angstrom X-ray structure of adamalysin II complexed with a peptide phosphonate inhibitor adopting a retro-binding mode., Cirilli M, Gallina C, Gavuzzo E, Giordano C, Gomis-Ruth FX, Gorini B, Kress LF, Mazza F, Paradisi MP, Pochetti G, Politi V, FEBS Lett. 1997 Dec 1;418(3):319-22. PMID:9428736

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