4fua

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:4fua.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:4fua.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_4fua| PDB=4fua | SCENE= }}
{{STRUCTURE_4fua| PDB=4fua | SCENE= }}
-
'''L-FUCULOSE-1-PHOSPHATE ALDOLASE COMPLEX WITH PGH'''
+
===L-FUCULOSE-1-PHOSPHATE ALDOLASE COMPLEX WITH PGH===
-
==Overview==
+
<!--
-
The structure of L-fuculose-1-phosphate aldolase in a cubic crystal form has been determined with and without the inhibitor phosphoglycolohydroxamate at 2.4 and 2.7 angstrom (1 angstrom = 0.1 nm) resolution, respectively. This inhibitor mimics the enediolate transition state of the substrate moiety dihydroxyacetone phosphate. The structures showed that dihydroxyacetone phosphate ligates the zinc ion of this metal-dependent class II aldolase with its hydroxyl and keto oxygen atoms, shifting Glu73 away from the zinc coordination sphere to a non-polar environment. At this position Glu73 accepts a proton in the initial reaction step, producing the enediolate which is then stabilized by the zinc ion. The other substrate moiety L-lactaldehyde was modeled, because no binding structure is yet available.
+
The line below this paragraph, {{ABSTRACT_PUBMED_8676381}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 8676381 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_8676381}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Zinc enzyme]]
[[Category: Zinc enzyme]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:24:03 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:37:31 2008''

Revision as of 10:37, 3 July 2008

Image:4fua.png

Template:STRUCTURE 4fua

L-FUCULOSE-1-PHOSPHATE ALDOLASE COMPLEX WITH PGH

Template:ABSTRACT PUBMED 8676381

About this Structure

4FUA is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Catalytic mechanism of the metal-dependent fuculose aldolase from Escherichia coli as derived from the structure., Dreyer MK, Schulz GE, J Mol Biol. 1996 Jun 14;259(3):458-66. PMID:8676381

Page seeded by OCA on Thu Jul 3 13:37:31 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4fua"
Personal tools