1dxw

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(New page: 200px<br /> <applet load="1dxw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dxw" /> '''STRUCTURE OF HETERO COMPLEX OF NON STRUCTUR...)
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==About this Structure==
==About this Structure==
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1DXW is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Hepatitis_c_virus_(isolate_1) Hepatitis c virus (isolate 1)]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DXW OCA]].
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1DXW is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Viruses Viruses]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Sites: CAT and ZNB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DXW OCA]].
==Reference==
==Reference==
Inhibitor binding induces active site stabilization of the HCV NS3 protein serine protease domain., Barbato G, Cicero DO, Cordier F, Narjes F, Gerlach B, Sambucini S, Grzesiek S, Matassa VG, De Francesco R, Bazzo R, EMBO J. 2000 Mar 15;19(6):1195-206. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10716920 10716920]
Inhibitor binding induces active site stabilization of the HCV NS3 protein serine protease domain., Barbato G, Cicero DO, Cordier F, Narjes F, Gerlach B, Sambucini S, Grzesiek S, Matassa VG, De Francesco R, Bazzo R, EMBO J. 2000 Mar 15;19(6):1195-206. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10716920 10716920]
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[[Category: Hepatitis c virus (isolate 1)]]
 
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Viruses]]
[[Category: Barbato, G.]]
[[Category: Barbato, G.]]
[[Category: Bazzo, R.]]
[[Category: Bazzo, R.]]
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[[Category: serine protease]]
[[Category: serine protease]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 19:22:42 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:31:31 2007''

Revision as of 10:26, 30 October 2007


1dxw

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STRUCTURE OF HETERO COMPLEX OF NON STRUCTURAL PROTEIN (NS) OF HEPATITIS C VIRUS (HCV) AND SYNTHETIC PEPTIDIC COMPOUND

Overview

Few structures of viral serine proteases, those encoded by the Sindbis and, Semliki Forest viruses, hepatitis C virus (HCV) and cytomegalovirus, have, been reported. In the life cycle of HCV a crucial role is played by a, chymotrypsin-like serine protease encoded at the N-terminus of the viral, NS3 protein, the solution structure of which we present here complexed, with a covalently bound reversible inhibitor. Unexpectedly, the residue in, the P2 position of the inhibitor induces an effective stabilization of the, catalytic His-Asp hydrogen bond, by shielding that region of the protease, from the solvent. This interaction appears crucial in the activation of, the enzyme catalytic machinery and represents an unprecedented observation, for this family of enzymes. Our data suggest that ... [(full description)]

About this Structure

1DXW is a [Single protein] structure of sequence from [Viruses] with ZN as [ligand]. Structure known Active Sites: CAT and ZNB. Full crystallographic information is available from [OCA].

Reference

Inhibitor binding induces active site stabilization of the HCV NS3 protein serine protease domain., Barbato G, Cicero DO, Cordier F, Narjes F, Gerlach B, Sambucini S, Grzesiek S, Matassa VG, De Francesco R, Bazzo R, EMBO J. 2000 Mar 15;19(6):1195-206. PMID:10716920

Page seeded by OCA on Tue Oct 30 12:31:31 2007

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