6acn

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{{STRUCTURE_6acn| PDB=6acn | SCENE= }}
{{STRUCTURE_6acn| PDB=6acn | SCENE= }}
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'''STRUCTURE OF ACTIVATED ACONITASE. FORMATION OF THE (4FE-4S) CLUSTER IN THE CRYSTAL'''
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===STRUCTURE OF ACTIVATED ACONITASE. FORMATION OF THE (4FE-4S) CLUSTER IN THE CRYSTAL===
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==Overview==
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The structure of activated pig heart aconitase [citrate(isocitrate) hydro-lyase, EC 4.2.1.3] containing a [4Fe-4S] cluster has been refined at 2.5-A resolution to a crystallographic residual of 18.2%. Comparison of this structure to the recently determined 2.1-A resolution structure of the inactive enzyme containing a [3Fe-4S] cluster, by difference Fourier analysis, shows that upon activation iron is inserted into the structure isomorphously. The common atoms of the [3Fe-4S] and [4Fe-4S] cores agree within 0.1 A; the three common cysteinyl S gamma ligand atoms agree within 0.25 A. The fourth ligand of the Fe inserted into the [3Fe-4S] cluster is a water or hydroxyl from solvent, consistent with the absence of a free cysteine ligand in the enzyme active site cleft and the isomorphism of the two structures. A water molecule occupies a similar site in the crystal structure of the inactive enzyme.
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The line below this paragraph, {{ABSTRACT_PUBMED_2726740}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 2726740 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2726740}}
==About this Structure==
==About this Structure==
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[[Category: Robbins, A H.]]
[[Category: Robbins, A H.]]
[[Category: Stout, C D.]]
[[Category: Stout, C D.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:38:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 14:14:10 2008''

Revision as of 11:14, 3 July 2008

Image:6acn.png

Template:STRUCTURE 6acn

STRUCTURE OF ACTIVATED ACONITASE. FORMATION OF THE (4FE-4S) CLUSTER IN THE CRYSTAL

Template:ABSTRACT PUBMED 2726740

About this Structure

6ACN is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Structure of activated aconitase: formation of the [4Fe-4S] cluster in the crystal., Robbins AH, Stout CD, Proc Natl Acad Sci U S A. 1989 May;86(10):3639-43. PMID:2726740

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