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6hbw

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[[Image:6hbw.gif|left|200px]]
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{{STRUCTURE_6hbw| PDB=6hbw | SCENE= }}
{{STRUCTURE_6hbw| PDB=6hbw | SCENE= }}
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'''Crystal structure of deoxy-human hemoglobin beta6 glu->trp'''
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===Crystal structure of deoxy-human hemoglobin beta6 glu->trp===
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==Overview==
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An atomic-level understanding of the interactions between hemoglobin molecules that contribute to the formation of pathological fibers in sickle cell disease remains elusive. By exploring crystal structures of mutant hemoglobins with altered polymerization properties, insight can be gained into sickle cell hemoglobin (HbS) polymerization. We present here the 2.0-A resolution deoxy crystal structure of human hemoglobin mutated to tryptophan at the beta6 position, the site of the glutamate --&gt; valine mutation in HbS. Unlike leucine and isoleucine, which promote polymerization relative to HbS, tryptophan inhibits polymerization. Our results provide explanations for the altered polymerization properties and reveal a fundamentally different double strand that may provide a model for interactions within a fiber and/or interactions leading to heterogeneous nucleation.
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{{ABSTRACT_PUBMED_9830011}}
==About this Structure==
==About this Structure==
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[[Category: Hemoglobin]]
[[Category: Hemoglobin]]
[[Category: Oxygen transport]]
[[Category: Oxygen transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:41:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 14:20:36 2008''

Revision as of 11:20, 3 July 2008

Image:6hbw.png

Template:STRUCTURE 6hbw

Crystal structure of deoxy-human hemoglobin beta6 glu->trp

Template:ABSTRACT PUBMED 9830011

About this Structure

6HBW is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of deoxy-human hemoglobin beta6 Glu --> Trp. Implications for the structure and formation of the sickle cell fiber., Harrington DJ, Adachi K, Royer WE Jr, J Biol Chem. 1998 Dec 4;273(49):32690-6. PMID:9830011

Page seeded by OCA on Thu Jul 3 14:20:36 2008

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