1dx5
From Proteopedia
(New page: 200px<br /> <applet load="1dx5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dx5, resolution 2.30Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1DX5 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from | + | 1DX5 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NDG, CA, NA and FMT as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Thrombin Thrombin]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]]. Structure known Active Sites: AC1, AC2, AC3 and AC4. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DX5 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| + | [[Category: Thrombin]] | ||
[[Category: Bode, W.]] | [[Category: Bode, W.]] | ||
[[Category: Fuentes-Prior, P.]] | [[Category: Fuentes-Prior, P.]] | ||
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[[Category: serine proteinase]] | [[Category: serine proteinase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:31:43 2007'' |
Revision as of 10:27, 30 October 2007
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CRYSTAL STRUCTURE OF THE THROMBIN-THROMBOMODULIN COMPLEX
Overview
The serine proteinase alpha-thrombin causes blood clotting through, proteolytic cleavage of fibrinogen and protease-activated receptors and, amplifies its own generation by activating the essential clotting factors, V and VIII. Thrombomodulin, a transmembrane thrombin receptor with six, contiguous epidermal growth factor-like domains (TME1-6), profoundly, alters the substrate specificity of thrombin from pro- to anticoagulant by, activating protein C. Activated protein C then deactivates the coagulation, cascade by degrading activated factors V and VIII. The, thrombin-thrombomodulin complex inhibits fibrinolysis by activating the, procarboxypeptidase thrombin-activatable fibrinolysis inhibitor. Here we, present the 2.3 A crystal structure of human alpha-thrombin bound to the, smallest ... [(full description)]
About this Structure
1DX5 is a [Protein complex] structure of sequences from [Homo sapiens] with NDG, CA, NA and FMT as [ligands]. Active as [Thrombin], with EC number [3.4.21.5]. Structure known Active Sites: AC1, AC2, AC3 and AC4. Full crystallographic information is available from [OCA].
Reference
Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex., Fuentes-Prior P, Iwanaga Y, Huber R, Pagila R, Rumennik G, Seto M, Morser J, Light DR, Bode W, Nature. 2000 Mar 30;404(6777):518-25. PMID:10761923
Page seeded by OCA on Tue Oct 30 12:31:43 2007
Categories: Homo sapiens | Protein complex | Thrombin | Bode, W. | Fuentes-Prior, P. | Huber, R. | Iwanaga, Y. | Light, D.R. | Morser, J. | Pagila, R. | Rumennik, G. | Seto, M. | CA | FMT | NA | NDG | Anticoagulant complex | Antifibrinolytic complex | Egf-like domains | Serine proteinase
