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6rlx

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[[Image:6rlx.gif|left|200px]]
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{{Seed}}
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[[Image:6rlx.png|left|200px]]
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{{STRUCTURE_6rlx| PDB=6rlx | SCENE= }}
{{STRUCTURE_6rlx| PDB=6rlx | SCENE= }}
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'''X-RAY STRUCTURE OF HUMAN RELAXIN AT 1.5 ANGSTROMS. COMPARISON TO INSULIN AND IMPLICATIONS FOR RECEPTOR BINDING DETERMINANTS'''
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===X-RAY STRUCTURE OF HUMAN RELAXIN AT 1.5 ANGSTROMS. COMPARISON TO INSULIN AND IMPLICATIONS FOR RECEPTOR BINDING DETERMINANTS===
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==Overview==
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The X-ray crystal structure of relaxin at 1.5 A resolution is reported for the physiologically active form of the human hormone. Relaxin is a small, two-chain polypeptide that is a member of the protein hormone family that also includes insulin and the insulin-like growth factors IGF-I and IGF-II. These hormones have biologically diverse activities but are structurally similar, sharing a distinctive pattern of cysteine and glycine residues. The predicted structural homology of relaxin to insulin is confirmed by this structural analysis; however, there are significant differences in the terminal regions of the b-chain. Although relaxin, like insulin, crystallizes as a dimer, the orientation of the molecules in the respective dimers is completely different. The region of the relaxin molecule proposed to be involved in receptor binding is part of the dimer interface, suggesting that some of the other residues contained in the dimer contact surface might be receptor binding determinants as well. The proposed receptor binding determinants for insulin likewise include residues at its dimer interface. However, because the dimer contacts of relaxin and insulin are quite different, it appears that these two structurally related hormones have evolved somewhat dissimilar mechanisms for receptor binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 1656049 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1656049}}
==About this Structure==
==About this Structure==
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[[Category: Kossiakoff, A A.]]
[[Category: Kossiakoff, A A.]]
[[Category: Randal, M.]]
[[Category: Randal, M.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:42:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 14:25:33 2008''

Revision as of 11:25, 3 July 2008

Image:6rlx.png

Template:STRUCTURE 6rlx

X-RAY STRUCTURE OF HUMAN RELAXIN AT 1.5 ANGSTROMS. COMPARISON TO INSULIN AND IMPLICATIONS FOR RECEPTOR BINDING DETERMINANTS

Template:ABSTRACT PUBMED 1656049

About this Structure

6RLX is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants., Eigenbrot C, Randal M, Quan C, Burnier J, O'Connell L, Rinderknecht E, Kossiakoff AA, J Mol Biol. 1991 Sep 5;221(1):15-21. PMID:1656049

Page seeded by OCA on Thu Jul 3 14:25:33 2008

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