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1xpa
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(New page: 200px<br /> <applet load="1xpa" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xpa" /> '''SOLUTION STRUCTURE OF THE DNA-AND RPA-BINDI...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1XPA is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1XPA OCA]]. | + | 1XPA is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: NUL. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1XPA OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: zinc-finger]] | [[Category: zinc-finger]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:31:53 2007'' |
Revision as of 10:27, 30 October 2007
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SOLUTION STRUCTURE OF THE DNA-AND RPA-BINDING DOMAIN OF THE HUMAN REPAIR FACTOR XPA, NMR, 1 STRUCTURE
Overview
The solution structure of the central domain of the human nucleotide, excision repair protein XPA, which binds to damaged DNA and replication, protein A (RPA), was determined by nuclear magnetic resonance (NMR), spectroscopy. The central domain consists of a zinc-containing subdomain, and a C-terminal subdomain. The zinc-containing subdomain has a compact, globular structure and is distinct from the zinc-fingers found in, transcription factors. The C-terminal subdomain folds into a novel, alpha/beta structure with a positively charged superficial cleft. From the, NMR spectra of the complexes, DNA and RPA binding surfaces are suggested.
About this Structure
1XPA is a [Single protein] structure of sequence from [Homo sapiens] with ZN as [ligand]. Structure known Active Site: NUL. Full crystallographic information is available from [OCA].
Reference
Solution structure of the DNA- and RPA-binding domain of the human repair factor XPA., Ikegami T, Kuraoka I, Saijo M, Kodo N, Kyogoku Y, Morikawa K, Tanaka K, Shirakawa M, Nat Struct Biol. 1998 Aug;5(8):701-6. PMID:9699634
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