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9gac

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[[Image:9gac.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_9gac| PDB=9gac | SCENE= }}
{{STRUCTURE_9gac| PDB=9gac | SCENE= }}
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'''PRECURSOR OF THE T152C MUTANT GLYCOSYLASPARAGINASE FROM FLAVOBACTERIUM MENINGOSEPTICUM'''
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===PRECURSOR OF THE T152C MUTANT GLYCOSYLASPARAGINASE FROM FLAVOBACTERIUM MENINGOSEPTICUM===
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==Overview==
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A variety of proteins, including glycosylasparaginase, have recently been found to activate functions by self-catalyzed peptide bond rearrangements from single-chain precursors. Here we present the 1.9 A crystal structures of glycosylasparaginase precursors that are able to autoproteolyze via an N --&gt; O acyl shift. Several conserved residues are aligned around the scissile peptide bond that is in a highly strained trans peptide bond configuration. The structure illustrates how a nucleophilic side chain may attack the scissile peptide bond at the immediate upstream backbone carbonyl and provides an understanding of the structural basis for peptide bond cleavage via an N --&gt; O or N --&gt; S acyl shift that is used by various groups of intramolecular autoprocessing proteins.
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The line below this paragraph, {{ABSTRACT_PUBMED_10490104}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10490104 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10490104}}
==About this Structure==
==About this Structure==
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[[Category: N-terminal nucleophile hydrolase]]
[[Category: N-terminal nucleophile hydrolase]]
[[Category: Precursor]]
[[Category: Precursor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:52:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jul 11 12:55:24 2008''

Revision as of 09:55, 11 July 2008

Image:9gac.png

Template:STRUCTURE 9gac

PRECURSOR OF THE T152C MUTANT GLYCOSYLASPARAGINASE FROM FLAVOBACTERIUM MENINGOSEPTICUM

Template:ABSTRACT PUBMED 10490104

About this Structure

9GAC is a Single protein structure of sequence from Elizabethkingia meningoseptica. Full crystallographic information is available from OCA.

Reference

Structural insights into the mechanism of intramolecular proteolysis., Xu Q, Buckley D, Guan C, Guo HC, Cell. 1999 Sep 3;98(5):651-61. PMID:10490104

Page seeded by OCA on Fri Jul 11 12:55:24 2008

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