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9ilb

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[[Image:9ilb.gif|left|200px]]
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{{Seed}}
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[[Image:9ilb.png|left|200px]]
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{{STRUCTURE_9ilb| PDB=9ilb | SCENE= }}
{{STRUCTURE_9ilb| PDB=9ilb | SCENE= }}
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'''HUMAN INTERLEUKIN-1 BETA'''
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===HUMAN INTERLEUKIN-1 BETA===
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==Overview==
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Water in the hydrophobic cavity of human interleukin 1beta, which was detected by NMR spectroscopy but was invisible by high resolution x-ray crystallography, has been mapped quantitatively by measurement and phasing of all of the low resolution x-ray diffraction data from a single crystal. Phases for the low resolution data were refined by iterative density modification of an initial flat solvent model outside the envelope of the atomic model. The refinement was restrained by the condition that the map of the difference between the electron density distribution in the full unit cell and that of the atomic model be flat within the envelope of the well ordered protein structure. Care was taken to avoid overfitting the diffraction data by maintaining phases for the high resolution data from the atomic model and by a resolution-dependent damping of the structure factor differences between data and model. The cavity region in the protein could accommodate up to four water molecules. The refined solvent difference map indicates that there are about two water molecules in the cavity region. This map is compatible with an atomic model of the water distribution refined by using XPLOR. About 70% of the time, there appears to be a water dimer in the central hydrophobic cavity, which is connected to the outside by two constricted channels occupied by single water molecules approximately 40% of the time on one side and approximately 10% on the other.
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The line below this paragraph, {{ABSTRACT_PUBMED_9874779}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9874779 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9874779}}
==About this Structure==
==About this Structure==
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[[Category: Yu, B.]]
[[Category: Yu, B.]]
[[Category: Interleukin]]
[[Category: Interleukin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:54:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jul 11 12:49:26 2008''

Revision as of 09:49, 11 July 2008

Image:9ilb.png

Template:STRUCTURE 9ilb

HUMAN INTERLEUKIN-1 BETA

Template:ABSTRACT PUBMED 9874779

About this Structure

9ILB is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Disordered water within a hydrophobic protein cavity visualized by x-ray crystallography., Yu B, Blaber M, Gronenborn AM, Clore GM, Caspar DL, Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):103-8. PMID:9874779

Page seeded by OCA on Fri Jul 11 12:49:26 2008

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