9pai

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[[Image:9pai.gif|left|200px]]
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{{STRUCTURE_9pai| PDB=9pai | SCENE= }}
{{STRUCTURE_9pai| PDB=9pai | SCENE= }}
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'''CLEAVED SUBSTRATE VARIANT OF PLASMINOGEN ACTIVATOR INHIBITOR-1'''
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===CLEAVED SUBSTRATE VARIANT OF PLASMINOGEN ACTIVATOR INHIBITOR-1===
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==Overview==
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Plasminogen activator inhibitor-1 (PAI-1) is unique among the serine proteinase inhibitors (serpins) in that it can adopt at least three different conformations (active, substrate and latent). We report the X-ray structure of a cleaved substrate variant of human PAI-1, which has a new beta-strand s4A formed by insertion of the amino-terminal portion of the reactive-site loop into beta-sheet A subsequent to cleavage. This is in contrast to the previous suggestion that the non-inhibitory function of substrate-type serpins is mainly due to an inability of the reactive-site loop to adopt this conformation. Comparison with the structure of latent PAI-1 provides insights into the molecular determinants responsible for the transition of the stressed active conformation to the thermostable latent conformation.
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(as it appears on PubMed at http://www.pubmed.gov), where 7552714 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7552714}}
==About this Structure==
==About this Structure==
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[[Category: Ranter, C J.De.]]
[[Category: Ranter, C J.De.]]
[[Category: Serpin]]
[[Category: Serpin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:54:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jul 11 12:59:51 2008''

Revision as of 09:59, 11 July 2008

Image:9pai.png

Template:STRUCTURE 9pai

CLEAVED SUBSTRATE VARIANT OF PLASMINOGEN ACTIVATOR INHIBITOR-1

Template:ABSTRACT PUBMED 7552714

About this Structure

9PAI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1., Aertgeerts K, De Bondt HL, De Ranter CJ, Declerck PJ, Nat Struct Biol. 1995 Oct;2(10):891-7. PMID:7552714

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