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2h6u

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{{STRUCTURE_2h6u| PDB=2h6u | SCENE= }}
{{STRUCTURE_2h6u| PDB=2h6u | SCENE= }}
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'''Crystal structure of 5-hydroxyisourate hydrolase (formerly known as TRP, transthyretin related protein)'''
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===Crystal structure of 5-hydroxyisourate hydrolase (formerly known as TRP, transthyretin related protein)===
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==Overview==
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During early vertebrate evolution, a duplication event in the gene encoding 5-hydroxyisourate hydrolase (HIUase), a widely distributed enzyme of purine metabolism, gave rise to transthyretin (TTR), a thyroid hormone transporter. We report here on the crystal structure of zebra fish HIUase in two different crystal forms. Despite the phylogenetic distance, this structure compares well with those of newly characterized bacterial HIUases, especially with regard to catalytic regions, which are highly preserved. Comparison with TTR structure reveals a highly conserved scaffold, harbouring distinct functional sites located in the same regions of the two vertebrate proteins. Residues that are differentially conserved in HIUases compared to TTR map in putative catalytic regions occupying significant portions of the two halves of a central channel that transverses the whole TTR protein. The evolution of TTR has been accompanied by remarkable changes of the HIUase active sites that gave rise to a channel open at both ends, thus allowing free access to hormone molecules.
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(as it appears on PubMed at http://www.pubmed.gov), where 16952372 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16952372}}
==About this Structure==
==About this Structure==
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[[Category: Trp]]
[[Category: Trp]]
[[Category: Uric acid degradation]]
[[Category: Uric acid degradation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 7 08:43:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:04:24 2008''

Revision as of 20:04, 27 July 2008

Image:2h6u.png

Template:STRUCTURE 2h6u

Crystal structure of 5-hydroxyisourate hydrolase (formerly known as TRP, transthyretin related protein)

Template:ABSTRACT PUBMED 16952372

About this Structure

2H6U is a Single protein structure of sequence from Danio rerio. Full crystallographic information is available from OCA.

Reference

Structure of zebra fish HIUase: insights into evolution of an enzyme to a hormone transporter., Zanotti G, Cendron L, Ramazzina I, Folli C, Percudani R, Berni R, J Mol Biol. 2006 Oct 13;363(1):1-9. Epub 2006 Aug 2. PMID:16952372

Page seeded by OCA on Sun Jul 27 23:04:24 2008

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