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2v9h

From Proteopedia

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{{STRUCTURE_2v9h| PDB=2v9h | SCENE= }}
{{STRUCTURE_2v9h| PDB=2v9h | SCENE= }}
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'''SOLUTION STRUCTURE OF AN ESCHERICHIA COLI YAET TANDEM POTRA DOMAIN'''
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===SOLUTION STRUCTURE OF AN ESCHERICHIA COLI YAET TANDEM POTRA DOMAIN===
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==Overview==
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Membranes of Gram-negative bacteria, mitochondria and chloroplasts receive and fold beta-barrel transmembrane proteins through the action of polypeptide transport-associated (POTRA) domains. In Escherichia coli, folding substrates are inserted into the outer membrane by the essential protein YaeT, a prototypic Omp85 protein. Here, the articulation between tandem POTRA domains in solution is defined by nuclear magnetic resonance (NMR) spectroscopy, indicating an unprecedented juxtaposition. The novel solution orientations of all five POTRA domains are revealed by small-angle X-ray scattering of the entire 46 kDa periplasmic region. NMR titration studies show that strands from YaeT's canonical folding substrate, PhoE, bind non-specifically along alternating sides of its mixed beta sheets, thus providing an ideal platform for helping to fold nascent outer-membrane proteins. Together, this provides the first structural model of how multiple POTRA domains recruit substrates from the periplasmic solution into the outer membrane.
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{{ABSTRACT_PUBMED_18430136}}
==About this Structure==
==About this Structure==
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2V9H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9H OCA].
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2V9H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9H OCA].
==Reference==
==Reference==
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[[Category: Protein-binding]]
[[Category: Protein-binding]]
[[Category: Yaet]]
[[Category: Yaet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:17:55 2008''

Revision as of 02:18, 29 July 2008

Image:2v9h.png

Template:STRUCTURE 2v9h

SOLUTION STRUCTURE OF AN ESCHERICHIA COLI YAET TANDEM POTRA DOMAIN

Template:ABSTRACT PUBMED 18430136

About this Structure

2V9H is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

Fold and function of polypeptide transport-associated domains responsible for delivering unfolded proteins to membranes., Knowles TJ, Jeeves M, Bobat S, Dancea F, McClelland D, Palmer T, Overduin M, Henderson IR, Mol Microbiol. 2008 Apr 21;. PMID:18430136

Page seeded by OCA on Tue Jul 29 05:17:55 2008

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