3cph

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{{STRUCTURE_3cph| PDB=3cph | SCENE= }}
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'''Crystal structure of Sec4 in complex with Rab-GDI'''
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===Crystal structure of Sec4 in complex with Rab-GDI===
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==Overview==
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RabGDI-facilitated extraction of prenylated Rab proteins from membranes plays an important role in vesicular membrane trafficking. The investigated thermodynamic properties of yeast Rab:GDI and Rab:MRS6 complexes demonstrated differences in the Rab binding properties of the closely related RabGDI and MRS6 proteins, consistent with their functional diversity. The importance of the Rab C-terminus and its prenylation for GDI/MRS6 binding was demonstrated using both biochemical and structural data. The presented structures of the apo-form yeast RabGDI and its two complexes with unprenylated Rab proteins, together with the earlier published structures of the prenylated Ypt1:RabGDI provide evidence of allosteric regulation of the GDI lipid binding site opening, which plays a key role in the proposed mechanism of GDI mediated Rab extraction. We suggest a model for the interaction of GDI with prenylated Rab proteins which incorporates a stepwise increase in affinity as the 3 different partial interactions are successively formed.
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==About this Structure==
==About this Structure==
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[[Category: Rab gtpase]]
[[Category: Rab gtpase]]
[[Category: Vesicular transport]]
[[Category: Vesicular transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 16 08:56:09 2008''

Revision as of 05:56, 16 July 2008

Image:3cph.png

Template:STRUCTURE 3cph

Crystal structure of Sec4 in complex with Rab-GDI

Template:ABSTRACT PUBMED 18426803

About this Structure

3CPH is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

A structural model of the GDI rab membrane extraction mechanism., Ignatev A, Kravchenko S, Rak A, Goody RS, Pylypenko O, J Biol Chem. 2008 Apr 20;. PMID:18426803

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