3c2i

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{{STRUCTURE_3c2i| PDB=3c2i | SCENE= }}
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'''The Crystal Structure of Methyl-CpG Binding Domain of Human MeCP2 in Complex with a Methylated DNA Sequence from BDNF'''
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===The Crystal Structure of Methyl-CpG Binding Domain of Human MeCP2 in Complex with a Methylated DNA Sequence from BDNF===
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==Overview==
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MeCP2 is an essential transcriptional repressor that mediates gene silencing through binding to methylated DNA. Binding specificity has been thought to depend on hydrophobic interactions between cytosine methyl groups and a hydrophobic patch within the methyl-CpG-binding domain (MBD). X-ray analysis of a methylated DNA-MBD cocrystal reveals, however, that the methyl groups make contact with a predominantly hydrophilic surface that includes tightly bound water molecules. This suggests that MeCP2 recognizes hydration of the major groove of methylated DNA rather than cytosine methylation per se. The MeCP2-DNA complex also identifies a unique structural role for T158, the residue most commonly mutated in Rett syndrome.
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(as it appears on PubMed at http://www.pubmed.gov), where 18313390 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18313390}}
==Disease==
==Disease==
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[[Category: Transcription regulator]]
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Revision as of 12:37, 28 July 2008

Image:3c2i.png

Template:STRUCTURE 3c2i

Contents

The Crystal Structure of Methyl-CpG Binding Domain of Human MeCP2 in Complex with a Methylated DNA Sequence from BDNF

Template:ABSTRACT PUBMED 18313390

Disease

Known disease associated with this structure: Angelman syndrome OMIM:[300005], Encephalopathy, neonatal severe OMIM:[300005], Mental retardation, X-linked, Lubs type OMIM:[300005], Mental retardation, X-linked, syndromic 13 OMIM:[300005], Rett syndrome OMIM:[300005], Rett syndrome, preserved speech variant OMIM:[300005], Autism, susceptibility to, X-linked-3 OMIM:[300005]

About this Structure

3C2I is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

MeCP2 binding to DNA depends upon hydration at methyl-CpG., Ho KL, McNae IW, Schmiedeberg L, Klose RJ, Bird AP, Walkinshaw MD, Mol Cell. 2008 Feb 29;29(4):525-31. PMID:18313390

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