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mRNA of the small C-terminal domain phosphatase 1 (SCP1/CTDSP1) protein, a component of the RE1-silencing transcription repressor (REST/NRSF) (6) (Fig. 1). REST represses the transcription of a large number of neuron-specific genes in nonneural cells (13). Thus, by reducing SCP1 expression in differentiating neurons, miR-124 may facilitate the derepression of the neuronal transcription program | mRNA of the small C-terminal domain phosphatase 1 (SCP1/CTDSP1) protein, a component of the RE1-silencing transcription repressor (REST/NRSF) (6) (Fig. 1). REST represses the transcription of a large number of neuron-specific genes in nonneural cells (13). Thus, by reducing SCP1 expression in differentiating neurons, miR-124 may facilitate the derepression of the neuronal transcription program | ||
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Revision as of 08:02, 15 May 2008
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mRNA of the small C-terminal domain phosphatase 1 (SCP1/CTDSP1) protein, a component of the RE1-silencing transcription repressor (REST/NRSF) (6) (Fig. 1). REST represses the transcription of a large number of neuron-specific genes in nonneural cells (13). Thus, by reducing SCP1 expression in differentiating neurons, miR-124 may facilitate the derepression of the neuronal transcription program
