We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1b8w

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1b8w" size="450" color="white" frame="true" align="right" spinBox="true" caption="1b8w" /> '''DEFENSIN-LIKE PEPTIDE 1'''<br /> ==Overview...)
Line 1: Line 1:
-
[[Image:1b8w.jpg|left|200px]]<br /><applet load="1b8w" size="450" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1b8w.jpg|left|200px]]<br /><applet load="1b8w" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1b8w" />
caption="1b8w" />
'''DEFENSIN-LIKE PEPTIDE 1'''<br />
'''DEFENSIN-LIKE PEPTIDE 1'''<br />
==Overview==
==Overview==
-
Three defensin-like peptides (DLPs) were isolated from platypus venom and, sequenced. One of these peptides, DLP-1, was synthesized chemically and, its three-dimensional structure was determined using NMR spectroscopy. The, main structural elements of this 42-residue peptide were an anti-parallel, beta-sheet comprising residues 15-18 and 37-40 and a small 3(10) helix, spanning residues 10-12. The overall three-dimensional fold is similar to, that of beta-defensin-12, and similar to the sodium-channel neurotoxin ShI, (Stichodactyla helianthus neurotoxin I). However, the side chains known to, be functionally important in beta-defensin-12 and ShI are not conserved in, DLP-1, suggesting that it has a different biological function. Consistent, with this contention, we showed that DLP-1 possesses no anti-microbial, properties and has no observable activity on rat dorsal-root-ganglion, sodium-channel currents.
+
Three defensin-like peptides (DLPs) were isolated from platypus venom and sequenced. One of these peptides, DLP-1, was synthesized chemically and its three-dimensional structure was determined using NMR spectroscopy. The main structural elements of this 42-residue peptide were an anti-parallel beta-sheet comprising residues 15-18 and 37-40 and a small 3(10) helix spanning residues 10-12. The overall three-dimensional fold is similar to that of beta-defensin-12, and similar to the sodium-channel neurotoxin ShI (Stichodactyla helianthus neurotoxin I). However, the side chains known to be functionally important in beta-defensin-12 and ShI are not conserved in DLP-1, suggesting that it has a different biological function. Consistent with this contention, we showed that DLP-1 possesses no anti-microbial properties and has no observable activity on rat dorsal-root-ganglion sodium-channel currents.
==About this Structure==
==About this Structure==
-
1B8W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Ornithorhynchus_anatinus Ornithorhynchus anatinus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1B8W OCA].
+
1B8W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Ornithorhynchus_anatinus Ornithorhynchus anatinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8W OCA].
==Reference==
==Reference==
Line 14: Line 14:
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Alewood, D.]]
[[Category: Alewood, D.]]
-
[[Category: Alewood, P.F.]]
+
[[Category: Alewood, P F.]]
-
[[Category: Fletcher, J.I.]]
+
[[Category: Fletcher, J I.]]
-
[[Category: Gallagher, C.H.]]
+
[[Category: Gallagher, C H.]]
-
[[Category: King, G.F.]]
+
[[Category: King, G F.]]
-
[[Category: Kuchel, P.W.]]
+
[[Category: Kuchel, P W.]]
-
[[Category: Nicholson, G.M.]]
+
[[Category: Nicholson, G M.]]
-
[[Category: Simpson, R.J.]]
+
[[Category: Simpson, R J.]]
[[Category: Smith, R.]]
[[Category: Smith, R.]]
-
[[Category: Sutherland, S.K.]]
+
[[Category: Sutherland, S K.]]
-
[[Category: Torres, A.M.]]
+
[[Category: Torres, A M.]]
[[Category: Wang, X.]]
[[Category: Wang, X.]]
[[Category: platypus]]
[[Category: platypus]]
[[Category: toxin]]
[[Category: toxin]]
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 11:27:57 2007''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:52:45 2008''

Revision as of 09:52, 21 February 2008

Image:1b8w.jpg

1b8w

Drag the structure with the mouse to rotate

DEFENSIN-LIKE PEPTIDE 1

Overview

Three defensin-like peptides (DLPs) were isolated from platypus venom and sequenced. One of these peptides, DLP-1, was synthesized chemically and its three-dimensional structure was determined using NMR spectroscopy. The main structural elements of this 42-residue peptide were an anti-parallel beta-sheet comprising residues 15-18 and 37-40 and a small 3(10) helix spanning residues 10-12. The overall three-dimensional fold is similar to that of beta-defensin-12, and similar to the sodium-channel neurotoxin ShI (Stichodactyla helianthus neurotoxin I). However, the side chains known to be functionally important in beta-defensin-12 and ShI are not conserved in DLP-1, suggesting that it has a different biological function. Consistent with this contention, we showed that DLP-1 possesses no anti-microbial properties and has no observable activity on rat dorsal-root-ganglion sodium-channel currents.

About this Structure

1B8W is a Single protein structure of sequence from Ornithorhynchus anatinus. Full crystallographic information is available from OCA.

Reference

Solution structure of a defensin-like peptide from platypus venom., Torres AM, Wang X, Fletcher JI, Alewood D, Alewood PF, Smith R, Simpson RJ, Nicholson GM, Sutherland SK, Gallagher CH, King GF, Kuchel PW, Biochem J. 1999 Aug 1;341 ( Pt 3):785-94. PMID:10417345

Page seeded by OCA on Thu Feb 21 11:52:45 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1b8w"
Personal tools