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2vn4

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{{STRUCTURE_2vn4| PDB=2vn4 | SCENE= }}
{{STRUCTURE_2vn4| PDB=2vn4 | SCENE= }}
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'''GLYCOSIDE HYDROLASE FAMILY 15 GLUCOAMYLASE FROM HYPOCREA JECORINA'''
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===GLYCOSIDE HYDROLASE FAMILY 15 GLUCOAMYLASE FROM HYPOCREA JECORINA===
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==Overview==
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The three-dimensional structure of a complete Hypocrea jecorina glucoamylase has been determined at 1.8 A resolution. The presented structure model includes the catalytic and starch binding domains and traces the course of the 37-residue linker segment. While the structures of other fungal and yeast glucoamylase catalytic and starch binding domains have been determined separately, this is the first intact structure that allows visualization of the juxtaposition of the starch binding domain relative to the catalytic domain. The detailed interactions we see between the catalytic and starch binding domains are confirmed in a second independent structure determination of the enzyme in a second crystal form. This second structure model exhibits an identical conformation compared to the first structure model, which suggests that the H. jecorina glucoamylase structure we report is independent of crystal lattice contact restraints and represents the three-dimensional structure found in solution. The proposed starch binding regions for the starch binding domain are aligned with the catalytic domain in the three-dimensional structure in a manner that supports the hypothesis that the starch binding domain serves to target the glucoamylase at sites where the starch granular matrix is disrupted and where the enzyme might most effectively function.
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==About this Structure==
==About this Structure==
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[[Category: Glycoside hydrolase family 15]]
[[Category: Glycoside hydrolase family 15]]
[[Category: Hypocrea jecorina]]
[[Category: Hypocrea jecorina]]
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Revision as of 15:40, 28 July 2008

Image:2vn4.png

Template:STRUCTURE 2vn4

GLYCOSIDE HYDROLASE FAMILY 15 GLUCOAMYLASE FROM HYPOCREA JECORINA

Template:ABSTRACT PUBMED 18457422

About this Structure

2VN4 is a Single protein structure of sequence from Hypocrea jecorina. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of an intact glycoside hydrolase family 15 glucoamylase from Hypocrea jecorina., Bott R, Saldajeno M, Cuevas W, Ward D, Scheffers M, Aehle W, Karkehabadi S, Sandgren M, Hansson H, Biochemistry. 2008 May 27;47(21):5746-54. Epub 2008 May 6. PMID:18457422

Page seeded by OCA on Mon Jul 28 18:40:22 2008

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