3c2g

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_3c2g", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
Line 1: Line 1:
-
[[Image:3c2g.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:3c2g.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_3c2g| PDB=3c2g | SCENE= }}
{{STRUCTURE_3c2g| PDB=3c2g | SCENE= }}
-
'''Crystal complex of SYS-1/POP-1 at 2.5A resolution'''
+
===Crystal complex of SYS-1/POP-1 at 2.5A resolution===
-
==Overview==
+
<!--
-
C. elegans SYS-1 has key functional characteristics of a canonical beta-catenin, but no significant sequence similarity. Here, we report the SYS-1 crystal structure, both on its own and in a complex with POP-1, the C. elegans TCF homolog. The two structures possess signature features of canonical beta-catenin and the beta-catenin/TCF complex that could not be predicted by sequence. Most importantly, SYS-1 bears 12 armadillo repeats and the SYS-1/POP-1 interface is anchored by a conserved salt-bridge, the "charged button." We also modeled structures for three other C. elegans beta-catenins to predict the molecular basis of their distinct binding properties. Finally, we generated a phylogenetic tree, using the region of highest structural similarity between SYS-1 and beta-catenin, and found that SYS-1 clusters robustly within the beta-catenin clade. We conclude that the SYS-1 protein belongs to the beta-catenin family and suggest that additional divergent beta-catenins await discovery.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18477457}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18477457 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18477457}}
==About this Structure==
==About this Structure==
Line 37: Line 41:
[[Category: Pop-1]]
[[Category: Pop-1]]
[[Category: Sys-1]]
[[Category: Sys-1]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 22 21:54:14 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:32:33 2008''

Revision as of 10:32, 29 July 2008

Image:3c2g.png

Template:STRUCTURE 3c2g

Crystal complex of SYS-1/POP-1 at 2.5A resolution

Template:ABSTRACT PUBMED 18477457

About this Structure

3C2G is a Protein complex structure of sequences from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

The C. elegans SYS-1 protein is a bona fide beta-catenin., Liu J, Phillips BT, Amaya MF, Kimble J, Xu W, Dev Cell. 2008 May;14(5):751-61. PMID:18477457

Page seeded by OCA on Tue Jul 29 13:32:33 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3c2g"
Personal tools