3crf

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{{STRUCTURE_3crf| PDB=3crf | SCENE= }}
{{STRUCTURE_3crf| PDB=3crf | SCENE= }}
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'''Electron Microscopy model of the Saf Pilus- Type B'''
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===Electron Microscopy model of the Saf Pilus- Type B===
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==Overview==
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Bacterial pili are important virulence factors involved in host cell attachment and/or biofilm formation, key steps in establishing and maintaining successful infection. Here we studied Salmonella atypical fimbriae (or Saf pili), formed by the conserved chaperone/usher pathway. In contrast to the well-established quaternary structure of typical/FGS-chaperone assembled, rod-shaped, chaperone/usher pili, little is known about the supramolecular organisation in atypical/FGL-chaperone assembled fimbriae. In our study, we have used negative stain electron microscopy and single-particle image analysis to determine the three-dimensional structure of the Salmonella typhimurium Saf pilus. Our results show atypical/FGL-chaperone assembled fimbriae are composed of highly flexible linear multi-subunit fibres that are formed by globular subunits connected to each other by short links giving a "beads on a string"-like appearance. Quantitative fitting of the atomic structure of the SafA pilus subunit into the electron density maps, in combination with linker modelling and energy minimisation, has enabled analysis of subunit arrangement and intersubunit interactions in the Saf pilus. Short intersubunit linker regions provide the molecular basis for flexibility of the Saf pilus by acting as molecular hinges allowing a large range of movement between consecutive subunits in the fibre.
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{{ABSTRACT_PUBMED_18448124}}
==About this Structure==
==About this Structure==
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[[Category: Safa protein polymer]]
[[Category: Safa protein polymer]]
[[Category: Type b saf pilus]]
[[Category: Type b saf pilus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:45:39 2008''

Revision as of 00:45, 28 July 2008

Image:3crf.png

Template:STRUCTURE 3crf

Electron Microscopy model of the Saf Pilus- Type B

Template:ABSTRACT PUBMED 18448124

About this Structure

3CRF is a Protein complex structure of sequences from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Structural analysis of the Saf pilus by electron microscopy and image processing., Salih O, Remaut H, Waksman G, Orlova EV, J Mol Biol. 2008 May 23;379(1):174-87. Epub 2008 Apr 3. PMID:18448124

Page seeded by OCA on Mon Jul 28 03:45:39 2008

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