1ykt

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[[Image:1ykt.gif|left|200px]]
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{{Seed}}
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[[Image:1ykt.png|left|200px]]
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{{STRUCTURE_1ykt| PDB=1ykt | SCENE= }}
{{STRUCTURE_1ykt| PDB=1ykt | SCENE= }}
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'''Trypsin/Bpti complex mutant'''
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===Trypsin/Bpti complex mutant===
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==Overview==
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Crystal structures, at 1.7 A resolution, were solved for complexes between each of two chemically synthesized partially folded analogues of bovine pancreatic trypsin inhibitor (BPTI) with the proteolytically inactive rat trypsin mutant S195A. The BPTI analogue termed [14-38](Abu) retains only the disulfide bond between Cys14 and Cys38, while Cys5, Cys30, Cys51, and Cys55 are replaced by isosteric alpha-amino-n-butyric acid residues. The analogue K26P,A27D[14-38](Abu) contains two further replacements, by statistically favored residues, in the type I beta-turn that has been suggested to be a main site for initiation of BPTI folding. As a control, the structure of the complex between S195A trypsin and wild-type BPTI was also solved. Despite significant differences in the degree of structure detected among these three BPTIs in solution by several biophysical techniques, their tertiary folds once bound to S195A trypsin in a crystalline lattice are essentially superimposable.
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(as it appears on PubMed at http://www.pubmed.gov), where 18054043 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18054043}}
==About this Structure==
==About this Structure==
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[[Category: Mutant]]
[[Category: Mutant]]
[[Category: Trypsin]]
[[Category: Trypsin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 22 22:17:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:53:01 2008''

Revision as of 03:53, 29 July 2008

Image:1ykt.png

Template:STRUCTURE 1ykt

Trypsin/Bpti complex mutant

Template:ABSTRACT PUBMED 18054043

About this Structure

1YKT is a Protein complex structure of sequences from Bos taurus and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Partially folded bovine pancreatic trypsin inhibitor analogues attain fully native structures when co-crystallized with S195A rat trypsin., Getun IV, Brown CK, Tulla-Puche J, Ohlendorf D, Woodward C, Barany G, J Mol Biol. 2008 Jan 18;375(3):812-23. Epub 2007 Nov 6. PMID:18054043

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