2fzv

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{{STRUCTURE_2fzv| PDB=2fzv | SCENE= }}
{{STRUCTURE_2fzv| PDB=2fzv | SCENE= }}
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'''Crystal Structure of an apo form of a Flavin-binding Protein from Shigella flexneri'''
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===Crystal Structure of an apo form of a Flavin-binding Protein from Shigella flexneri===
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==Overview==
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The arsH gene or its homologs are a frequent part of the arsenic resistance system in bacteria and eukaryotes. Although a specific biological function of the gene product is unknown, the ArsH protein was annotated as a member of the NADPH-dependent FMN reductase family based on a conserved (T/S)XRXXSX(T/S) fingerprint motif common for FMN binding proteins. Presented here are the first crystal structure of an ArsH protein from Shigella flexneri refined at 1.7 A resolution and results of enzymatic activity assays that revealed a strong NADPH-dependent FMN reductase and low azoreductase activities. The ArsH apo protein has an alpha/beta/alpha-fold typical for FMN binding proteins. The asymmetric unit consists of four monomers, which form a tetramer. Buried surface analysis suggests that this tetramer is likely to be the relevant biological assembly. Dynamic light scattering experiments are consistent with this hypothesis and show that ArsH in solution at room temperature does exist predominantly in the tetrameric form.
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(as it appears on PubMed at http://www.pubmed.gov), where 17962405 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17962405}}
==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Unknown function]]
[[Category: Unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 22 22:22:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:37:09 2008''

Revision as of 15:37, 28 July 2008

Image:2fzv.png

Template:STRUCTURE 2fzv

Crystal Structure of an apo form of a Flavin-binding Protein from Shigella flexneri

Template:ABSTRACT PUBMED 17962405

About this Structure

2FZV is a Single protein structure of sequence from Shigella flexneri 2a. Full crystallographic information is available from OCA.

Reference

Crystal structure of an apo form of Shigella flexneri ArsH protein with an NADPH-dependent FMN reductase activity., Vorontsov II, Minasov G, Brunzelle JS, Shuvalova L, Kiryukhina O, Collart FR, Anderson WF, Protein Sci. 2007 Nov;16(11):2483-90. PMID:17962405

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