2gp3

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{{STRUCTURE_2gp3| PDB=2gp3 | SCENE= }}
{{STRUCTURE_2gp3| PDB=2gp3 | SCENE= }}
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'''Crystal structure of the catalytic core comain of jmjd2a'''
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===Crystal structure of the catalytic core comain of jmjd2a===
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==Overview==
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Posttranslational modifications of histones regulate chromatin structure and gene expression. Histone demethylases, members of a newly emerging transcription-factor family, remove methyl groups from the lysine residues of the histone tails and thereby regulate the transcriptional activity of target genes. JmjC-domain-containing proteins have been predicted to be demethylases. For example, the JmjC-containing protein JMJD2A has been characterized as a H3-K9me3- and H3-K36me3-specific demethylase. Here, structures of the catalytic-core domain of JMJD2A with and without alpha-ketoglutarate in the presence of Fe2+ have been determined by X-ray crystallography. The structure of the core domain, consisting of the JmjN domain, the JmjC domain, the C-terminal domain, and a zinc-finger motif, revealed the unique elements that form a potential substrate binding pocket. Sited-directed mutagenesis in conjunction with demethylase activity assays allowed us to propose a molecular model for substrate selection by the JMJD2 histone demethylase family.
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{{ABSTRACT_PUBMED_16677698}}
==About this Structure==
==About this Structure==
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[[Category: Metal binding protein]]
[[Category: Metal binding protein]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 22 22:23:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:11:04 2008''

Revision as of 12:11, 28 July 2008

Image:2gp3.png

Template:STRUCTURE 2gp3

Crystal structure of the catalytic core comain of jmjd2a

Template:ABSTRACT PUBMED 16677698

About this Structure

2GP3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural insights into histone demethylation by JMJD2 family members., Chen Z, Zang J, Whetstine J, Hong X, Davrazou F, Kutateladze TG, Simpson M, Mao Q, Pan CH, Dai S, Hagman J, Hansen K, Shi Y, Zhang G, Cell. 2006 May 19;125(4):691-702. Epub 2006 May 4. PMID:16677698

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