3bs1

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{{STRUCTURE_3bs1| PDB=3bs1 | SCENE= }}
{{STRUCTURE_3bs1| PDB=3bs1 | SCENE= }}
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'''Structure of the Staphylococcus aureus AgrA LytTR Domain Bound to DNA Reveals a Beta Fold with a Novel Mode of Binding'''
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===Structure of the Staphylococcus aureus AgrA LytTR Domain Bound to DNA Reveals a Beta Fold with a Novel Mode of Binding===
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==Overview==
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The LytTR domain is a DNA-binding motif found within the AlgR/AgrA/LytR family of transcription factors that regulate virulence factor and toxin gene expression in pathogenic bacteria. This previously uncharacterized domain lacks sequence similarity with proteins of known structure. The crystal structure of the DNA-binding domain of Staphylococcus aureus AgrA complexed with a DNA pentadecamer duplex has been determined at 1.6 A resolution. The structure establishes a 10-stranded beta fold for the LytTR domain and reveals its mode of interaction with DNA. Residues within loop regions of AgrA contact two successive major grooves and the intervening minor groove on one face of the oligonucleotide duplex, inducing a substantial bend in the DNA. Loss of DNA binding upon substitution of key interacting residues in AgrA supports the observed binding mode. This mode of protein-DNA interaction provides a potential target for future antimicrobial drug design.
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(as it appears on PubMed at http://www.pubmed.gov), where 18462677 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18462677}}
==About this Structure==
==About this Structure==
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[[Category: Transcription regulator]]
[[Category: Transcription regulator]]
[[Category: Two-component regulatory system]]
[[Category: Two-component regulatory system]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 22 22:35:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:32:59 2008''

Revision as of 04:33, 29 July 2008

Image:3bs1.png

Template:STRUCTURE 3bs1

Structure of the Staphylococcus aureus AgrA LytTR Domain Bound to DNA Reveals a Beta Fold with a Novel Mode of Binding

Template:ABSTRACT PUBMED 18462677

About this Structure

3BS1 is a Protein complex structure of sequences from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Structure of the Staphylococcus aureus AgrA LytTR Domain Bound to DNA Reveals a Beta Fold with an Unusual Mode of Binding., Sidote DJ, Barbieri CM, Wu T, Stock AM, Structure. 2008 May;16(5):727-35. PMID:18462677

Page seeded by OCA on Tue Jul 29 07:32:59 2008

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