1bax
From Proteopedia
(New page: 200px<br /><applet load="1bax" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bax" /> '''MASON-PFIZER MONKEY VIRUS MATRIX PROTEIN, NM...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1bax.gif|left|200px]]<br /><applet load="1bax" size=" | + | [[Image:1bax.gif|left|200px]]<br /><applet load="1bax" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1bax" /> | caption="1bax" /> | ||
'''MASON-PFIZER MONKEY VIRUS MATRIX PROTEIN, NMR, AVERAGE STRUCTURE'''<br /> | '''MASON-PFIZER MONKEY VIRUS MATRIX PROTEIN, NMR, AVERAGE STRUCTURE'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The Mason-Pfizer monkey virus (M-PMV) is the prototype of the type D | + | The Mason-Pfizer monkey virus (M-PMV) is the prototype of the type D retroviruses. In type B and D retroviruses, the Gag protein pre-assembles before association with the membrane, whereas in type C retroviruses (lentiviruses, BLV/HTLV group) Gag is targeted efficiently to the plasma membrane, where the particle formation occurs. The N-terminal domain of Gag, the matrix protein (MA), plays a critical role in determining this morphogenic difference. We have determined the three-dimensional solution structure of the M-PMV MA by heteronuclear nuclear magnetic resonance. The protein contains four alpha-helices that are structurally similar to the known type C MA structures. This similarity implies possible common assembly units and membrane-binding mechanisms for type C and B/D retroviruses. In addition to this, the interpretation of mutagenesis data has enabled us to identify, for the first time, the structural basis of a putative intracellular targeting motif. |
==About this Structure== | ==About this Structure== | ||
| - | 1BAX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Simian_mason-pfizer_virus Simian mason-pfizer virus]. This structure | + | 1BAX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Simian_mason-pfizer_virus Simian mason-pfizer virus]. This structure supersedes the now removed PDB entry 1AT7. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAX OCA]. |
==Reference== | ==Reference== | ||
| Line 13: | Line 13: | ||
[[Category: Simian mason-pfizer virus]] | [[Category: Simian mason-pfizer virus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Conte, M | + | [[Category: Conte, M R.]] |
[[Category: Hunter, E.]] | [[Category: Hunter, E.]] | ||
[[Category: Klikova, M.]] | [[Category: Klikova, M.]] | ||
| Line 23: | Line 23: | ||
[[Category: polyprotein]] | [[Category: polyprotein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:53:20 2008'' |
Revision as of 09:53, 21 February 2008
|
MASON-PFIZER MONKEY VIRUS MATRIX PROTEIN, NMR, AVERAGE STRUCTURE
Overview
The Mason-Pfizer monkey virus (M-PMV) is the prototype of the type D retroviruses. In type B and D retroviruses, the Gag protein pre-assembles before association with the membrane, whereas in type C retroviruses (lentiviruses, BLV/HTLV group) Gag is targeted efficiently to the plasma membrane, where the particle formation occurs. The N-terminal domain of Gag, the matrix protein (MA), plays a critical role in determining this morphogenic difference. We have determined the three-dimensional solution structure of the M-PMV MA by heteronuclear nuclear magnetic resonance. The protein contains four alpha-helices that are structurally similar to the known type C MA structures. This similarity implies possible common assembly units and membrane-binding mechanisms for type C and B/D retroviruses. In addition to this, the interpretation of mutagenesis data has enabled us to identify, for the first time, the structural basis of a putative intracellular targeting motif.
About this Structure
1BAX is a Single protein structure of sequence from Simian mason-pfizer virus. This structure supersedes the now removed PDB entry 1AT7. Full crystallographic information is available from OCA.
Reference
The three-dimensional solution structure of the matrix protein from the type D retrovirus, the Mason-Pfizer monkey virus, and implications for the morphology of retroviral assembly., Conte MR, Klikova M, Hunter E, Ruml T, Matthews S, EMBO J. 1997 Oct 1;16(19):5819-26. PMID:9312040
Page seeded by OCA on Thu Feb 21 11:53:20 2008
