3bk3

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{{STRUCTURE_3bk3| PDB=3bk3 | SCENE= }}
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'''Crystal structure of the complex of BMP-2 and the first Von Willebrand domain type C of Crossveinless-2'''
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===Crystal structure of the complex of BMP-2 and the first Von Willebrand domain type C of Crossveinless-2===
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==Overview==
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Crossveinless 2 (CV-2) is an extracellular BMP modulator protein belonging to the Chordin family. During development it is expressed at sites of high BMP signaling and like Chordin CV-2 can either enhance or inhibit BMP activity. CV-2 binds to BMP-2 via its N-terminal Von Willebrand factor type C (VWC) domain 1. Here we report the structure of the complex between CV-2 VWC1 and BMP-2. The tripartite VWC1 binds BMP-2 only through a short N-terminal segment, called clip, and subdomain (SD) 1. Mutational analysis establishes that the clip segment and SD1 together create high-affinity BMP-2 binding. All four receptor-binding sites of BMP-2 are blocked in the complex, demonstrating that VWC1 acts as competitive inhibitor for all receptor types. In vivo experiments reveal that the BMP-enhancing (pro-BMP) activity of CV-2 is independent of BMP-2 binding by VWC1, showing that pro- and anti-BMP activities are structurally separated in CV-2.
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{{ABSTRACT_PUBMED_18477456}}
==About this Structure==
==About this Structure==
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[[Category: Secreted]]
[[Category: Secreted]]
[[Category: Tgf-beta superfamily]]
[[Category: Tgf-beta superfamily]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 28 09:19:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:23:40 2008''

Revision as of 11:23, 29 July 2008

Image:3bk3.png

Template:STRUCTURE 3bk3

Crystal structure of the complex of BMP-2 and the first Von Willebrand domain type C of Crossveinless-2

Template:ABSTRACT PUBMED 18477456

About this Structure

3BK3 is a Protein complex structure of sequences from Danio rerio and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding., Zhang JL, Qiu LY, Kotzsch A, Weidauer S, Patterson L, Hammerschmidt M, Sebald W, Mueller TD, Dev Cell. 2008 May;14(5):739-50. PMID:18477456

Page seeded by OCA on Tue Jul 29 14:23:40 2008

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