1x26

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[[Image:1x26.gif|left|200px]]
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{{Seed}}
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[[Image:1x26.png|left|200px]]
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{{STRUCTURE_1x26| PDB=1x26 | SCENE= }}
{{STRUCTURE_1x26| PDB=1x26 | SCENE= }}
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'''Solution structure of the AA-mismatch DNA complexed with naphthyridine-azaquinolone'''
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===Solution structure of the AA-mismatch DNA complexed with naphthyridine-azaquinolone===
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==Overview==
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DNA trinucleotide repeats, particularly CXG, are common within the human genome. However, expansion of trinucleotide repeats is associated with a number of disorders, including Huntington disease, spinobulbar muscular atrophy and spinocerebellar ataxia. In these cases, the repeat length is known to correlate with decreased age of onset and disease severity. Repeat expansion of (CAG)n, (CTG)n and (CGG)n trinucleotides may be related to the increased stability of alternative DNA hairpin structures consisting of CXG-CXG triads with X-X mismatches. Small-molecule ligands that selectively bound to CAG repeats could provide an important probe for determining repeat length and an important tool for investigating the in vivo repeat extension mechanism. Here we report that napthyridine-azaquinolone (NA, 1) is a ligand for CAG repeats and can be used as a diagnostic tool for determining repeat length. We show by NMR spectroscopy that binding of NA to CAG repeats induces the extrusion of a cytidine nucleotide from the DNA helix.
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The line below this paragraph, {{ABSTRACT_PUBMED_16407992}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16407992 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16407992}}
==About this Structure==
==About this Structure==
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1X26 is a [[Protein complex]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X26 OCA].
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1X26 is a [[Protein complex]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X26 OCA].
==Reference==
==Reference==
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[[Category: Dna]]
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[[Category: Drug]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 28 09:27:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:20:32 2008''

Revision as of 08:20, 29 July 2008

Image:1x26.png

Template:STRUCTURE 1x26

Solution structure of the AA-mismatch DNA complexed with naphthyridine-azaquinolone

Template:ABSTRACT PUBMED 16407992

About this Structure

1X26 is a Protein complex structure. Full experimental information is available from OCA.

Reference

Small-molecule ligand induces nucleotide flipping in (CAG)n trinucleotide repeats., Nakatani K, Hagihara S, Goto Y, Kobori A, Hagihara M, Hayashi G, Kyo M, Nomura M, Mishima M, Kojima C, Nat Chem Biol. 2005 Jun;1(1):39-43. Epub 2005 May 24. PMID:16407992

Page seeded by OCA on Tue Jul 29 11:20:32 2008

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