2ose

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{{STRUCTURE_2ose| PDB=2ose | SCENE= }}
{{STRUCTURE_2ose| PDB=2ose | SCENE= }}
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'''Crystal Structure of the Mimivirus Cyclophilin'''
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===Crystal Structure of the Mimivirus Cyclophilin===
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==Overview==
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Although multiple viruses utilize host cell cyclophilins, including severe acute respiratory syndrome (SARS) and human immunodeficiency virus type-1(HIV-1), their role in infection is poorly understood. To help elucidate these roles, we have characterized the first virally encoded cyclophilin (mimicyp) derived from the largest virus discovered to date (the Mimivirus) that is also a causative agent of pneumonia in humans. Mimicyp adopts a typical cyclophilin-fold, yet it also forms trimers unlike any previously characterized homologue. Strikingly, immunofluorescence assays reveal that mimicyp localizes to the surface of the mature virion, as recently proposed for several viruses that recruit host cell cyclophilins such as SARS and HIV-1. Additionally mimicyp lacks peptidyl-prolyl isomerase activity in contrast to human cyclophilins. Thus, this study suggests that cyclophilins, whether recruited from host cells (i.e. HIV-1 and SARS) or virally encoded (i.e. Mimivirus), are localized on viral surfaces for at least a subset of viruses.
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(as it appears on PubMed at http://www.pubmed.gov), where 18342330 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18342330}}
==About this Structure==
==About this Structure==
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[[Category: Isomerase]]
[[Category: Isomerase]]
[[Category: Mimivirus]]
[[Category: Mimivirus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 28 09:30:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:14:39 2008''

Revision as of 18:14, 28 July 2008

Image:2ose.png

Template:STRUCTURE 2ose

Crystal Structure of the Mimivirus Cyclophilin

Template:ABSTRACT PUBMED 18342330

About this Structure

2OSE is a Single protein structure of sequence from Mimivirus. Full crystallographic information is available from OCA.

Reference

Structural, biochemical, and in vivo characterization of the first virally encoded cyclophilin from the Mimivirus., Thai V, Renesto P, Fowler CA, Brown DJ, Davis T, Gu W, Pollock DD, Kern D, Raoult D, Eisenmesser EZ, J Mol Biol. 2008 Apr 18;378(1):71-86. Epub 2007 Aug 29. PMID:18342330

Page seeded by OCA on Mon Jul 28 21:14:39 2008

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