1ahj
From Proteopedia
(New page: 200px<br /> <applet load="1ahj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ahj, resolution 2.65Å" /> '''NITRILE HYDRATASE''...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1AHJ is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/ ]] with FE as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.84 4.2.1.84]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AHJ OCA]]. | + | 1AHJ is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Rhodococcus_sp._r312 Rhodococcus sp. r312]] with FE as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Nitrile_hydratase Nitrile hydratase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.84 4.2.1.84]]. Structure known Active Sites: FEA, FEC, FEE and FEG. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AHJ OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of nitrile hydratase reveals a novel iron centre in a novel fold., Huang W, Jia J, Cummings J, Nelson M, Schneider G, Lindqvist Y, Structure. 1997 May 15;5(5):691-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9195885 9195885] | Crystal structure of nitrile hydratase reveals a novel iron centre in a novel fold., Huang W, Jia J, Cummings J, Nelson M, Schneider G, Lindqvist Y, Structure. 1997 May 15;5(5):691-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9195885 9195885] | ||
| + | [[Category: Nitrile hydratase]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| + | [[Category: Rhodococcus sp. r312]] | ||
[[Category: Huang, W.]] | [[Category: Huang, W.]] | ||
[[Category: Lindqvist, Y.]] | [[Category: Lindqvist, Y.]] | ||
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[[Category: non-heme iron]] | [[Category: non-heme iron]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:34:04 2007'' |
Revision as of 10:29, 30 October 2007
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NITRILE HYDRATASE
Overview
BACKGROUND: Nitrile hydratases are unusual metalloenzymes that catalyze, the hydration of nitriles to their corresponding amides. They are used as, biocatalysts in acrylamide production, one of the few commercial scale, bioprocesses, as well as in environmental remediation for the removal of, nitriles from waste streams. Nitrile hydratases are composed of two, subunits, alpha and beta, and they contain one iron atom per alphabeta, unit. We have determined the crystal structure of photoactivated, iron-containing nitrile hydratase from Rhodococcus sp. R312 to 2.65 A, resolution as a first step in the elucidation of its catalytic mechanism., RESULTS: The alpha subunit consists of a long N-terminal arm and a, C-terminal domain that forms a novel fold. This fold can be described as a, four ... [(full description)]
About this Structure
1AHJ is a [Protein complex] structure of sequences from [Rhodococcus sp. r312] with FE as [ligand]. Active as [Nitrile hydratase], with EC number [4.2.1.84]. Structure known Active Sites: FEA, FEC, FEE and FEG. Full crystallographic information is available from [OCA].
Reference
Crystal structure of nitrile hydratase reveals a novel iron centre in a novel fold., Huang W, Jia J, Cummings J, Nelson M, Schneider G, Lindqvist Y, Structure. 1997 May 15;5(5):691-9. PMID:9195885
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