1bv1
From Proteopedia
(New page: 200px<br /><applet load="1bv1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bv1, resolution 2.0Å" /> '''BIRCH POLLEN ALLERGEN...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1bv1.gif|left|200px]]<br /><applet load="1bv1" size=" | + | [[Image:1bv1.gif|left|200px]]<br /><applet load="1bv1" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1bv1, resolution 2.0Å" /> | caption="1bv1, resolution 2.0Å" /> | ||
'''BIRCH POLLEN ALLERGEN BET V 1'''<br /> | '''BIRCH POLLEN ALLERGEN BET V 1'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The three-dimensional structure of the major birch pollen allergen, the | + | The three-dimensional structure of the major birch pollen allergen, the 17,500 M(r) acidic protein Bet v 1 (from the birch, Betula verrucosa), is presented as determined both in the crystalline state by X-ray diffraction and in solution by nuclear magnetic resonance (NMR) spectroscopy. This is the first experimentally determined structure of a clinically important inhalant major allergen, estimated to cause allergy in 5-10 million individuals worldwide. The structure shows three regions on the molecular surface predicted to harbour cross-reactive B-cell epitopes which provide a structural basis for the allergic symptoms that birch pollen allergic patients show when they encounter pollens from related trees such as hazel, alder and hornbeam. The structure also shows an unusual feature, a 30 A-long forked cavity that penetrates the entire protein. |
==About this Structure== | ==About this Structure== | ||
| - | 1BV1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Betula_pendula Betula pendula]. Full crystallographic information is available from [http:// | + | 1BV1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Betula_pendula Betula pendula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BV1 OCA]. |
==Reference== | ==Reference== | ||
| Line 15: | Line 15: | ||
[[Category: Gajhede, M.]] | [[Category: Gajhede, M.]] | ||
[[Category: Ipsen, H.]] | [[Category: Ipsen, H.]] | ||
| - | [[Category: Joostvan, R | + | [[Category: Joostvan, R J.]] |
| - | [[Category: Larson, J | + | [[Category: Larson, J N.]] |
[[Category: Lowenstein, H.]] | [[Category: Lowenstein, H.]] | ||
[[Category: Osmark, P.]] | [[Category: Osmark, P.]] | ||
| - | [[Category: Poulsen, F | + | [[Category: Poulsen, F M.]] |
[[Category: Schou, C.]] | [[Category: Schou, C.]] | ||
| - | [[Category: Spangfort, M | + | [[Category: Spangfort, M D.]] |
[[Category: allergen]] | [[Category: allergen]] | ||
[[Category: pathogenesis-related protein]] | [[Category: pathogenesis-related protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:59:22 2008'' |
Revision as of 09:59, 21 February 2008
|
BIRCH POLLEN ALLERGEN BET V 1
Overview
The three-dimensional structure of the major birch pollen allergen, the 17,500 M(r) acidic protein Bet v 1 (from the birch, Betula verrucosa), is presented as determined both in the crystalline state by X-ray diffraction and in solution by nuclear magnetic resonance (NMR) spectroscopy. This is the first experimentally determined structure of a clinically important inhalant major allergen, estimated to cause allergy in 5-10 million individuals worldwide. The structure shows three regions on the molecular surface predicted to harbour cross-reactive B-cell epitopes which provide a structural basis for the allergic symptoms that birch pollen allergic patients show when they encounter pollens from related trees such as hazel, alder and hornbeam. The structure also shows an unusual feature, a 30 A-long forked cavity that penetrates the entire protein.
About this Structure
1BV1 is a Single protein structure of sequence from Betula pendula. Full crystallographic information is available from OCA.
Reference
X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy., Gajhede M, Osmark P, Poulsen FM, Ipsen H, Larsen JN, Joost van Neerven RJ, Schou C, Lowenstein H, Spangfort MD, Nat Struct Biol. 1996 Dec;3(12):1040-5. PMID:8946858
Page seeded by OCA on Thu Feb 21 11:59:22 2008
