2rhf

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{{Seed}}
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{{STRUCTURE_2rhf| PDB=2rhf | SCENE= }}
{{STRUCTURE_2rhf| PDB=2rhf | SCENE= }}
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'''D. radiodurans RecQ HRDC domain 3'''
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===D. radiodurans RecQ HRDC domain 3===
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==Overview==
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RecQ helicases are critical for maintaining genome integrity in organisms ranging from bacteria to humans by participating in a complex network of DNA metabolic pathways. Their diverse cellular functions require specialization and coordination of multiple protein domains that integrate catalytic functions with DNA-protein and protein-protein interactions. The RecQ helicase from Deinococcus radiodurans (DrRecQ) is unusual among RecQ family members in that it has evolved to utilize three 'Helicase and RNaseD C-terminal' (HRDC) domains to regulate its activity. In this report, we describe the high-resolution structure of the C-terminal-most HRDC domain of DrRecQ. The structure reveals unusual electrostatic surface features that distinguish it from other HRDC domains. Mutation of individual residues in these regions affects the DNA binding affinity of DrRecQ and its ability to unwind a partial duplex DNA substrate. Taken together, the results suggest the unusual electrostatic surface features of the DrRecQ HRDC domain may be important for inter-domain interactions that regulate structure-specific DNA binding and help direct DrRecQ to specific recombination/repair sites.
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(as it appears on PubMed at http://www.pubmed.gov), where 18411208 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18411208}}
==About this Structure==
==About this Structure==
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[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: Recq]]
[[Category: Recq]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 4 09:59:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:50:50 2008''

Revision as of 21:50, 28 July 2008

Image:2rhf.png

Template:STRUCTURE 2rhf

D. radiodurans RecQ HRDC domain 3

Template:ABSTRACT PUBMED 18411208

About this Structure

2RHF is a Single protein structure of sequence from Deinococcus radiodurans r1. Full crystallographic information is available from OCA.

Reference

Structure and function of the regulatory C-terminal HRDC domain from Deinococcus radiodurans RecQ., Killoran MP, Keck JL, Nucleic Acids Res. 2008 May;36(9):3139-49. Epub 2008 Apr 13. PMID:18411208

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