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3c1v

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{{STRUCTURE_3c1v| PDB=3c1v | SCENE= }}
{{STRUCTURE_3c1v| PDB=3c1v | SCENE= }}
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'''The 1.5 A Crystal structure of Ca2+-bound S100A4'''
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===The 1.5 A Crystal structure of Ca2+-bound S100A4===
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==Overview==
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S100A4 takes part in control of tumour cell migration and contributes to metastatic spread in in vivo models. In the active dimeric Ca(2+)-bound state it interacts with multiple intracellular targets. Conversely, oligomeric forms of S100A4 are linked with the extracellular function of this protein. We report the 1.5A X-ray crystal structure of Ca(2+)-bound S100A4 and use it to identify the residues involved in target recognition and to derive a model of the oligomeric state. We applied stopped-flow analysis of tyrosine fluorescence to derive kinetics of S100A4 activation by Ca(2+) (k(on)=3.5muM(-1)s(-1), k(off)=20s(-1)).
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{{ABSTRACT_PUBMED_18435928}}
==About this Structure==
==About this Structure==
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[[Category: Calcium-bound]]
[[Category: Calcium-bound]]
[[Category: S100a4]]
[[Category: S100a4]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 4 10:01:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:35:19 2008''

Revision as of 08:35, 29 July 2008

Image:3c1v.png

Template:STRUCTURE 3c1v

The 1.5 A Crystal structure of Ca2+-bound S100A4

Template:ABSTRACT PUBMED 18435928

About this Structure

3C1V is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Ca(2+)-form and Ca(2+)-binding kinetics of metastasis-associated protein, S100A4., Gingras AR, Basran J, Prescott A, Kriajevska M, Bagshaw CR, Barsukov IL, FEBS Lett. 2008 May 28;582(12):1651-6. Epub 2008 Apr 22. PMID:18435928

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