1sj9

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{{STRUCTURE_1sj9| PDB=1sj9 | SCENE= }}
{{STRUCTURE_1sj9| PDB=1sj9 | SCENE= }}
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'''Crystal structure of the uridine phosphorylase from Salmonella typhimurium at 2.5A resolution'''
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===Crystal structure of the uridine phosphorylase from Salmonella typhimurium at 2.5A resolution===
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==Overview==
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Uridine phosphorylase (UPh) catalyzes the phosphorolytic cleavage of the C-N glycosidic bond of uridine to ribose 1-phosphate and uracil in the pyrimidine-salvage pathway. The crystal structure of the Salmonella typhimurium uridine phosphorylase (StUPh) has been determined at 2.5 A resolution and refined to an R factor of 22.1% and an Rfree of 27.9%. The hexameric StUPh displays 32 point-group symmetry and utilizes both twofold and threefold non-crystallographic axes. A phosphate is bound at the active site and forms hydrogen bonds to Arg91, Arg30, Thr94 and Gly26 of one monomer and Arg48 of an adjacent monomer. The hexameric StUPh model reveals a close structural relationship to Escherichia coli uridine phosphorylase (EcUPh).
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(as it appears on PubMed at http://www.pubmed.gov), where 16511035 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16511035}}
==About this Structure==
==About this Structure==
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[[Category: Nucleoside phosphorylase]]
[[Category: Nucleoside phosphorylase]]
[[Category: Transferase]]
[[Category: Transferase]]
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Revision as of 23:15, 27 July 2008

Image:1sj9.png

Template:STRUCTURE 1sj9

Crystal structure of the uridine phosphorylase from Salmonella typhimurium at 2.5A resolution

Template:ABSTRACT PUBMED 16511035

About this Structure

1SJ9 is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Preliminary investigation of the three-dimensional structure of Salmonella typhimurium uridine phosphorylase in the crystalline state., Dontsova MV, Gabdoulkhakov AG, Molchan OK, Lashkov AA, Garber MB, Mironov AS, Zhukhlistova NE, Morgunova EY, Voelter W, Betzel C, Zhang Y, Ealick SE, Mikhailov AM, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Apr 1;61(Pt, 4):337-40. Epub 2005 Mar 24. PMID:16511035

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