2vl8
From Proteopedia
(New page: '''Unreleased structure''' The entry 2vl8 is ON HOLD until Paper Publication Authors: Jank, T., Ziegler, M.O.P., Schulz, G.E., Aktories, K. Description: CRYSTAL STRUCTURE OF THE CATALY...) |
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| + | {{STRUCTURE_2vl8| PDB=2vl8 | SCENE= }} | ||
| - | + | '''CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LETHAL TOXIN FROM CLOSTRIDIUM SORDELLII IN COMPLEX WITH UDP, CASTANOSPERMINE AND CALCIUM ION''' | |
| - | Description: CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LETHAL TOXIN FROM CLOSTRIDIUM SORDELLII IN COMPLEX WITH UDP, CASTANOSPERMINE AND CALCIUM ION | ||
| + | ==Overview== | ||
| + | Castanospermine was identified as an inhibitor of the Rho/Ras-glucosylating Clostridium sordellii lethal toxin and Clostridium difficile toxin B. Microinjection of castanospermine into embryonic bovine lung cells prevented the cytotoxic effects of toxins. The crystal structure of the glucosyltransferase domain of C. sordellii lethal toxin in complex with castanospermine, UDP and a calcium ion was solved at a resolution of 2.3A. The inhibitor binds in a conformation that brings its four hydroxyl groups and its N-atom almost exactly in the positions of the four hydroxyls and of the ring oxygen of the glucosyl moiety of UDP-glucose, respectively. | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun | + | ==About this Structure== |
| + | 2VL8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_sordellii Clostridium sordellii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL8 OCA]. | ||
| + | |||
| + | ==Reference== | ||
| + | Inhibition of the glucosyltransferase activity of clostridial Rho/Ras-glucosylating toxins by castanospermine., Jank T, Ziegler MO, Schulz GE, Aktories K, FEBS Lett. 2008 Jun 25;582(15):2277-82. Epub 2008 May 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18505687 18505687] | ||
| + | [[Category: Clostridium sordellii]] | ||
| + | [[Category: Single protein]] | ||
| + | [[Category: Aktories, K.]] | ||
| + | [[Category: Jank, T.]] | ||
| + | [[Category: Schulz, G E.]] | ||
| + | [[Category: Ziegler, M O.P.]] | ||
| + | [[Category: Glycosyltransferase]] | ||
| + | [[Category: Toxin]] | ||
| + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:04:53 2008'' | ||
Revision as of 09:04, 18 June 2008
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LETHAL TOXIN FROM CLOSTRIDIUM SORDELLII IN COMPLEX WITH UDP, CASTANOSPERMINE AND CALCIUM ION
Overview
Castanospermine was identified as an inhibitor of the Rho/Ras-glucosylating Clostridium sordellii lethal toxin and Clostridium difficile toxin B. Microinjection of castanospermine into embryonic bovine lung cells prevented the cytotoxic effects of toxins. The crystal structure of the glucosyltransferase domain of C. sordellii lethal toxin in complex with castanospermine, UDP and a calcium ion was solved at a resolution of 2.3A. The inhibitor binds in a conformation that brings its four hydroxyl groups and its N-atom almost exactly in the positions of the four hydroxyls and of the ring oxygen of the glucosyl moiety of UDP-glucose, respectively.
About this Structure
2VL8 is a Single protein structure of sequence from Clostridium sordellii. Full crystallographic information is available from OCA.
Reference
Inhibition of the glucosyltransferase activity of clostridial Rho/Ras-glucosylating toxins by castanospermine., Jank T, Ziegler MO, Schulz GE, Aktories K, FEBS Lett. 2008 Jun 25;582(15):2277-82. Epub 2008 May 27. PMID:18505687 Page seeded by OCA on Wed Jun 18 12:04:53 2008
