3cds

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(New page: '''Unreleased structure''' The entry 3cds is ON HOLD until Paper Publication Authors: Pochetti, G., Montanari, R., Mazza, F., Crestani, M., Godio, C., Loiodice, F., Fracchiolla, G., Lav...)
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'''Unreleased structure'''
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[[Image:3cds.jpg|left|200px]]
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The entry 3cds is ON HOLD until Paper Publication
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{{STRUCTURE_3cds| PDB=3cds | SCENE= }}
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Authors: Pochetti, G., Montanari, R., Mazza, F., Crestani, M., Godio, C., Loiodice, F., Fracchiolla, G., Lavecchia, A., Novellino, E.
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===Crystal structure of the complex between PPAR-gamma and the agonist LT248 (clofibric acid analogue)===
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Description: Crystal structure of the complex between PPAR-gamma and the agonist LT248 (clofibric acid analogue)
 
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{{ABSTRACT_PUBMED_19053776}}
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 09:31:25 2008''
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==About this Structure==
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3CDS is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CDS OCA].
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==Reference==
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Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design., Montanari R, Saccoccia F, Scotti E, Crestani M, Godio C, Gilardi F, Loiodice F, Fracchiolla G, Laghezza A, Tortorella P, Lavecchia A, Novellino E, Mazza F, Aschi M, Pochetti G, J Med Chem. 2008 Dec 25;51(24):7768-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19053776 19053776]
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Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors., Xu HE, Lambert MH, Montana VG, Plunket KD, Moore LB, Collins JL, Oplinger JA, Kliewer SA, Gampe RT Jr, McKee DD, Moore JT, Willson TM, Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13919-24. Epub 2001 Nov 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11698662 11698662]
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[[Category: Homo sapiens]]
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[[Category: Mazza, F.]]
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[[Category: Montanari, R.]]
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[[Category: Pochetti, G.]]
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[[Category: Activator]]
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[[Category: Alternative splicing]]
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[[Category: Bundle of alpha-helices and a small four-stranded beta-sheet]]
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[[Category: Diabetes mellitus]]
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[[Category: Disease mutation]]
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[[Category: Dna-binding]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Obesity]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Receptor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 31 10:18:38 2008''

Revision as of 08:18, 31 December 2008

Image:3cds.jpg

Template:STRUCTURE 3cds

Crystal structure of the complex between PPAR-gamma and the agonist LT248 (clofibric acid analogue)

Template:ABSTRACT PUBMED 19053776

About this Structure

3CDS is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design., Montanari R, Saccoccia F, Scotti E, Crestani M, Godio C, Gilardi F, Loiodice F, Fracchiolla G, Laghezza A, Tortorella P, Lavecchia A, Novellino E, Mazza F, Aschi M, Pochetti G, J Med Chem. 2008 Dec 25;51(24):7768-76. PMID:19053776

Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors., Xu HE, Lambert MH, Montana VG, Plunket KD, Moore LB, Collins JL, Oplinger JA, Kliewer SA, Gampe RT Jr, McKee DD, Moore JT, Willson TM, Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13919-24. Epub 2001 Nov 6. PMID:11698662

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