3bu0

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{{Seed}}
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{{STRUCTURE_3bu0| PDB=3bu0 | SCENE= }}
{{STRUCTURE_3bu0| PDB=3bu0 | SCENE= }}
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'''crystal structure of human ABH2 cross-linked to dsDNA with cofactors'''
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===crystal structure of human ABH2 cross-linked to dsDNA with cofactors===
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==Overview==
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Escherichia coli AlkB and its human homologues ABH2 and ABH3 repair DNA/RNA base lesions by using a direct oxidative dealkylation mechanism. ABH2 has the primary role of guarding mammalian genomes against 1-meA damage by repairing this lesion in double-stranded DNA (dsDNA), whereas AlkB and ABH3 preferentially repair single-stranded DNA (ssDNA) lesions and can repair damaged bases in RNA. Here we show the first crystal structures of AlkB-dsDNA and ABH2-dsDNA complexes, stabilized by a chemical cross-linking strategy. This study reveals that AlkB uses an unprecedented base-flipping mechanism to access the damaged base: it squeezes together the two bases flanking the flipped-out one to maintain the base stack, explaining the preference of AlkB for repairing ssDNA lesions over dsDNA ones. In addition, the first crystal structure of ABH2, presented here, provides a structural basis for designing inhibitors of this human DNA repair protein.
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The line below this paragraph, {{ABSTRACT_PUBMED_18432238}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18432238 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18432238}}
==About this Structure==
==About this Structure==
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[[Category: Oxidoreductase/dna complex]]
[[Category: Oxidoreductase/dna complex]]
[[Category: Protein/dna interaction]]
[[Category: Protein/dna interaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 10:57:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:13:33 2008''

Revision as of 10:13, 27 July 2008

Image:3bu0.png

Template:STRUCTURE 3bu0

crystal structure of human ABH2 cross-linked to dsDNA with cofactors

Template:ABSTRACT PUBMED 18432238

About this Structure

3BU0 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA., Yang CG, Yi C, Duguid EM, Sullivan CT, Jian X, Rice PA, He C, Nature. 2008 Apr 24;452(7190):961-5. PMID:18432238

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