1c8z
From Proteopedia
(New page: 200px<br /><applet load="1c8z" size="450" color="white" frame="true" align="right" spinBox="true" caption="1c8z, resolution 1.9Å" /> '''C-TERMINAL DOMAIN OF ...) |
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| - | [[Image:1c8z.gif|left|200px]]<br /><applet load="1c8z" size=" | + | [[Image:1c8z.gif|left|200px]]<br /><applet load="1c8z" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1c8z, resolution 1.9Å" /> | caption="1c8z, resolution 1.9Å" /> | ||
'''C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN'''<br /> | '''C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Tubby-like proteins (TULPs) are found in a broad range of multicellular | + | Tubby-like proteins (TULPs) are found in a broad range of multicellular organisms. In mammals, genetic mutation of tubby or other TULPs can result in one or more of three disease phenotypes: obesity (from which the name "tubby" is derived), retinal degeneration, and hearing loss. These disease phenotypes indicate a vital role for tubby proteins; however, no biochemical function has yet been ascribed to any member of this protein family. A structure-directed approach was employed to investigate the biological function of these proteins. The crystal structure of the core domain from mouse tubby was determined at a resolution of 1.9 angstroms. From primarily structural clues, experiments were devised, the results of which suggest that TULPs are a unique family of bipartite transcription factors. |
==About this Structure== | ==About this Structure== | ||
| - | 1C8Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with PO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1C8Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=PO4:'>PO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C8Z OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Boggon, T | + | [[Category: Boggon, T J.]] |
| - | [[Category: Myers, S | + | [[Category: Myers, S C.]] |
[[Category: Shapiro, L.]] | [[Category: Shapiro, L.]] | ||
[[Category: PO4]] | [[Category: PO4]] | ||
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[[Category: tubby filled-barrel]] | [[Category: tubby filled-barrel]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:03:42 2008'' |
Revision as of 10:03, 21 February 2008
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C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN
Overview
Tubby-like proteins (TULPs) are found in a broad range of multicellular organisms. In mammals, genetic mutation of tubby or other TULPs can result in one or more of three disease phenotypes: obesity (from which the name "tubby" is derived), retinal degeneration, and hearing loss. These disease phenotypes indicate a vital role for tubby proteins; however, no biochemical function has yet been ascribed to any member of this protein family. A structure-directed approach was employed to investigate the biological function of these proteins. The crystal structure of the core domain from mouse tubby was determined at a resolution of 1.9 angstroms. From primarily structural clues, experiments were devised, the results of which suggest that TULPs are a unique family of bipartite transcription factors.
About this Structure
1C8Z is a Single protein structure of sequence from Mus musculus with as ligand. Full crystallographic information is available from OCA.
Reference
Implication of tubby proteins as transcription factors by structure-based functional analysis., Boggon TJ, Shan WS, Santagata S, Myers SC, Shapiro L, Science. 1999 Dec 10;286(5447):2119-25. PMID:10591637
Page seeded by OCA on Thu Feb 21 12:03:42 2008
