2k1a

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[[Image:2k1a.jpg|left|200px]]
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{{Seed}}
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[[Image:2k1a.png|left|200px]]
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{{STRUCTURE_2k1a| PDB=2k1a | SCENE= }}
{{STRUCTURE_2k1a| PDB=2k1a | SCENE= }}
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'''Bicelle-embedded integrin alpha(IIB) transmembrane segment'''
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===Bicelle-embedded integrin alpha(IIB) transmembrane segment===
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==Overview==
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Integrin cell-adhesion receptors transduce signals bidirectionally across the plasma membrane via the single-pass transmembrane segments of each alpha and beta subunit. While the beta3 transmembrane segment consists of a linear 29-residue alpha-helix, the structure of the alphaIIb transmembrane segment reveals a linear 24-residue alpha-helix (Ile-966 -Lys-989) followed by a backbone reversal that packs Phe-992-Phe-993 against the transmembrane helix. The length of the alphaIIb transmembrane helix implies the absence of a significant transmembrane helix tilt in contrast to its partnering beta3 subunit. Sequence alignment shows Gly-991-Phe-993 to be fully conserved among all 18 human integrin alpha subunits, suggesting that their unusual structural motif is prototypical for integrin alpha subunits. The alphaIIb transmembrane structure demonstrates a level of complexity within the membrane that is beyond simple transmembrane helices and forms the structural basis for assessing the extent of structural and topological rearrangements upon alphaIIb-beta3 association, i.e. integrin transmembrane signaling.
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The line below this paragraph, {{ABSTRACT_PUBMED_18417472}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18417472 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18417472}}
==About this Structure==
==About this Structure==
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2K1A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K1A OCA].
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2K1A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K1A OCA].
==Reference==
==Reference==
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[[Category: Receptor]]
[[Category: Receptor]]
[[Category: Single-pass transmembrane segment]]
[[Category: Single-pass transmembrane segment]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:16:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:27:21 2008''

Revision as of 14:27, 27 July 2008

Image:2k1a.png

Template:STRUCTURE 2k1a

Bicelle-embedded integrin alpha(IIB) transmembrane segment

Template:ABSTRACT PUBMED 18417472

About this Structure

2K1A is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of the Integrin {alpha}IIb Transmembrane Segment., Lau TL, Dua V, Ulmer TS, J Biol Chem. 2008 Jun 6;283(23):16162-8. Epub 2008 Apr 16. PMID:18417472

Page seeded by OCA on Sun Jul 27 17:27:21 2008

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