2vl7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2vl7.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2vl7.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2vl7| PDB=2vl7 | SCENE= }}
{{STRUCTURE_2vl7| PDB=2vl7 | SCENE= }}
-
'''STRUCTURE OF S. TOKODAII XPD4'''
+
===STRUCTURE OF S. TOKODAII XPD4===
-
==Overview==
+
<!--
-
The XPD helicase (Rad3 in Saccharomyces cerevisiae) is a component of transcription factor IIH (TFIIH), which functions in transcription initiation and Nucleotide Excision Repair in eukaryotes, catalyzing DNA duplex opening localized to the transcription start site or site of DNA damage, respectively. XPD has a 5' to 3' polarity and the helicase activity is dependent on an iron-sulfur cluster binding domain, a feature that is conserved in related helicases such as FancJ. The xpd gene is the target of mutation in patients with xeroderma pigmentosum, trichothiodystrophy, and Cockayne's syndrome, characterized by a wide spectrum of symptoms ranging from cancer susceptibility to neurological and developmental defects. The 2.25 A crystal structure of XPD from the crenarchaeon Sulfolobus tokodaii, presented here together with detailed biochemical analyses, allows a molecular understanding of the structural basis for helicase activity and explains the phenotypes of xpd mutations in humans.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18510925}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18510925 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18510925}}
==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Helicase]]
[[Category: Helicase]]
[[Category: Unknown function]]
[[Category: Unknown function]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:17:58 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:59:10 2008''

Revision as of 10:59, 28 July 2008

Image:2vl7.png

Template:STRUCTURE 2vl7

STRUCTURE OF S. TOKODAII XPD4

Template:ABSTRACT PUBMED 18510925

About this Structure

2VL7 is a Single protein structure of sequence from Sulfolobus tokodaii. Full crystallographic information is available from OCA.

Reference

Structure of the DNA repair helicase XPD., Liu H, Rudolf J, Johnson KA, McMahon SA, Oke M, Carter L, McRobbie AM, Brown SE, Naismith JH, White MF, Cell. 2008 May 30;133(5):801-12. PMID:18510925

Page seeded by OCA on Mon Jul 28 13:59:10 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vl7"
Personal tools