2j3v
From Proteopedia
(New page: 200px<br /> <applet load="2j3v" size="450" color="white" frame="true" align="right" spinBox="true" caption="2j3v, resolution 2.11Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2J3V is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]] with SO4 and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J3V OCA]]. | + | 2J3V is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]] with SO4 and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J3V OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: toxin]] | [[Category: toxin]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:39:02 2007'' |
Revision as of 10:34, 30 October 2007
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CRYSTAL STRUCTURE OF THE ENZYMATIC COMPONENT C2-I OF THE C2-TOXIN FROM CLOSTRIDIUM BOTULINUM AT PH 3.0
Overview
C2 toxin from Clostridium botulinum is composed of the enzyme component, C2-I, which ADP-ribosylates actin, and the binding and translocation, component C2-II, responsible for the interaction with eukaryotic cell, receptors and the following endocytosis. Three C2-I crystal structures at, resolutions of up to 1.75 A are presented together with a crystal, structure of C2-II at an appreciably lower resolution and a model of the, prepore formed by fragment C2-IIa. The C2-I structure was determined at pH, 3.0 and at pH 6.1. The structural differences are small, indicating that, C2-I does not unfold, even at a pH value as low as 3.0. The ADP-ribosyl, transferase activity of C2-I was determined for alpha and beta/gamma-actin, and related to that of Iota toxin and of mutant S361R of C2-I that, ... [(full description)]
About this Structure
2J3V is a [Single protein] structure of sequence from [Clostridium botulinum] with SO4 and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure and action of the binary C2 toxin from Clostridium botulinum., Schleberger C, Hochmann H, Barth H, Aktories K, Schulz GE, J Mol Biol. 2006 Dec 8;364(4):705-15. Epub 2006 Sep 5. PMID:17027031
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