1csn
From Proteopedia
(New page: 200px<br /><applet load="1csn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1csn, resolution 2.0Å" /> '''BINARY COMPLEX OF CAS...) |
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| - | [[Image:1csn.gif|left|200px]]<br /><applet load="1csn" size=" | + | [[Image:1csn.gif|left|200px]]<br /><applet load="1csn" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1csn, resolution 2.0Å" /> | caption="1csn, resolution 2.0Å" /> | ||
'''BINARY COMPLEX OF CASEIN KINASE-1 WITH MGATP'''<br /> | '''BINARY COMPLEX OF CASEIN KINASE-1 WITH MGATP'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The structure of a truncated variant of casein kinase-1 from | + | The structure of a truncated variant of casein kinase-1 from Schizosaccharomyces pombe, has been determined in complex with MgATP at 2.0 A resolution. The model resembles the 'closed', ATP-bound conformations of the cyclin-dependent kinase 2 and the cAMP-dependent protein kinase, with clear differences in the structure of surface loops that impart unique features to casein kinase-1. The structure is of unphosphorylated, active conformation of casein kinase-1 and the peptide-binding site is fully accessible to substrate. |
==About this Structure== | ==About this Structure== | ||
| - | 1CSN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe] with MG, SO4 and ATP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1CSN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=ATP:'>ATP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CSN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Cheng, X.]] | [[Category: Cheng, X.]] | ||
| - | [[Category: Xu, R | + | [[Category: Xu, R M.]] |
[[Category: ATP]] | [[Category: ATP]] | ||
[[Category: MG]] | [[Category: MG]] | ||
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[[Category: phosphotransferase]] | [[Category: phosphotransferase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:09:18 2008'' |
Revision as of 10:09, 21 February 2008
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BINARY COMPLEX OF CASEIN KINASE-1 WITH MGATP
Overview
The structure of a truncated variant of casein kinase-1 from Schizosaccharomyces pombe, has been determined in complex with MgATP at 2.0 A resolution. The model resembles the 'closed', ATP-bound conformations of the cyclin-dependent kinase 2 and the cAMP-dependent protein kinase, with clear differences in the structure of surface loops that impart unique features to casein kinase-1. The structure is of unphosphorylated, active conformation of casein kinase-1 and the peptide-binding site is fully accessible to substrate.
About this Structure
1CSN is a Single protein structure of sequence from Schizosaccharomyces pombe with , and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of casein kinase-1, a phosphate-directed protein kinase., Xu RM, Carmel G, Sweet RM, Kuret J, Cheng X, EMBO J. 1995 Mar 1;14(5):1015-23. PMID:7889932
Page seeded by OCA on Thu Feb 21 12:09:18 2008
Categories: Schizosaccharomyces pombe | Single protein | Cheng, X. | Xu, R M. | ATP | MG | SO4 | Phosphotransferase
