1d0b
From Proteopedia
(New page: 200px<br /><applet load="1d0b" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d0b, resolution 1.86Å" /> '''INTERNALIN B LEUCINE...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1d0b.jpg|left|200px]]<br /><applet load="1d0b" size=" | + | [[Image:1d0b.jpg|left|200px]]<br /><applet load="1d0b" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1d0b, resolution 1.86Å" /> | caption="1d0b, resolution 1.86Å" /> | ||
'''INTERNALIN B LEUCINE RICH REPEAT DOMAIN'''<br /> | '''INTERNALIN B LEUCINE RICH REPEAT DOMAIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The L. monocytogenes protein lnlB activates phosphoinositide 3-kinase and | + | The L. monocytogenes protein lnlB activates phosphoinositide 3-kinase and induces phagocytosis in several mammalian cell types. The 1.86 A resolution X-ray crystal structure of the leucine-rich repeat domain of lnlB that is both necessary and sufficient to induce phagocytosis is presented here. The structure supports a crucial role for calcium in host cell invasion by L. monocytogenes and supplies a rationale for its function. Calciums are bound to the protein in an unusually exposed manner that suggests that the metals may act as a bridge between lnlB and mammalian cell surface receptors. The structure also identifies surfaces on the curved and elongated molecule that may constitute additional interaction sites in forming a bacterial-mammalian signaling complex. |
==About this Structure== | ==About this Structure== | ||
| - | 1D0B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1D0B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D0B OCA]. |
==Reference== | ==Reference== | ||
| Line 21: | Line 21: | ||
[[Category: leucine rich repeat]] | [[Category: leucine rich repeat]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:11:34 2008'' |
Revision as of 10:11, 21 February 2008
|
INTERNALIN B LEUCINE RICH REPEAT DOMAIN
Overview
The L. monocytogenes protein lnlB activates phosphoinositide 3-kinase and induces phagocytosis in several mammalian cell types. The 1.86 A resolution X-ray crystal structure of the leucine-rich repeat domain of lnlB that is both necessary and sufficient to induce phagocytosis is presented here. The structure supports a crucial role for calcium in host cell invasion by L. monocytogenes and supplies a rationale for its function. Calciums are bound to the protein in an unusually exposed manner that suggests that the metals may act as a bridge between lnlB and mammalian cell surface receptors. The structure also identifies surfaces on the curved and elongated molecule that may constitute additional interaction sites in forming a bacterial-mammalian signaling complex.
About this Structure
1D0B is a Single protein structure of sequence from Listeria monocytogenes with as ligand. Full crystallographic information is available from OCA.
Reference
Structure of the lnlB leucine-rich repeats, a domain that triggers host cell invasion by the bacterial pathogen L. monocytogenes., Marino M, Braun L, Cossart P, Ghosh P, Mol Cell. 1999 Dec;4(6):1063-72. PMID:10635330
Page seeded by OCA on Thu Feb 21 12:11:34 2008
