1bsx
From Proteopedia
(New page: 200px<br /> <applet load="1bsx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bsx, resolution 3.7Å" /> '''STRUCTURE AND SPECIF...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1BSX is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with T3 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BSX OCA]]. | + | 1BSX is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with T3 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Sites: A and B. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BSX OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: specificity interaction site]] | [[Category: specificity interaction site]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:40:39 2007'' |
Revision as of 10:35, 30 October 2007
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STRUCTURE AND SPECIFICITY OF NUCLEAR RECEPTOR-COACTIVATOR INTERACTIONS
Overview
Combinatorial regulation of transcription implies flexible yet precise, assembly of multiprotein regulatory complexes in response to signals., Biochemical and crystallographic analyses revealed that hormone binding, leads to the formation of a hydrophobic groove within the ligand binding, domain (LBD) of the thyroid hormone receptor that interacts with an LxxLL, motif-containing alpha-helix from GRIP1, a coactivator. Residues, immediately adjacent to the motif modulate the affinity of the, interaction; the motif and the adjacent sequences are employed to, different extents in binding to different receptors. Such interactions of, amphipathic alpha-helices with hydrophobic grooves define protein, interfaces in other regulatory complexes as well. We suggest that these, common structural ... [(full description)]
About this Structure
1BSX is a [Single protein] structure of sequence from [Homo sapiens] with T3 as [ligand]. Structure known Active Sites: A and B. Full crystallographic information is available from [OCA].
Reference
Structure and specificity of nuclear receptor-coactivator interactions., Darimont BD, Wagner RL, Apriletti JW, Stallcup MR, Kushner PJ, Baxter JD, Fletterick RJ, Yamamoto KR, Genes Dev. 1998 Nov 1;12(21):3343-56. PMID:9808622
Page seeded by OCA on Tue Oct 30 12:40:39 2007
