1n9j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
 +
{{Seed}}
[[Image:1n9j.png|left|200px]]
[[Image:1n9j.png|left|200px]]
Line 9: Line 10:
{{STRUCTURE_1n9j| PDB=1n9j | SCENE= }}
{{STRUCTURE_1n9j| PDB=1n9j | SCENE= }}
-
'''Solution Structure of the 3D domain swapped dimer of Stefin A'''
+
===Solution Structure of the 3D domain swapped dimer of Stefin A===
-
==Overview==
+
<!--
-
Cystatins, an amyloid-forming structural superfamily, form highly stable, domain-swapped dimers at physiological protein concentrations. In chicken cystatin, the active monomer is a kinetic trap en route to dimerization, and any changes in solution conditions or mutations that destabilize the folded state shorten the lifetime of the monomeric form. In such circumstances, amyloidogenesis will start from conditions where a domain-swapped dimer is the most prevalent species. Domain swapping occurs by a rearrangement of loop I, generating the new intermonomer interface between strands 2 and 3. The transition state for dimerization has a high level of hydrophobic group exposure, indicating that gross conformational perturbation is required for domain swapping to occur. Dimerization also occurs when chicken cystatin is in its reduced, molten-globule state, implying that the organization of secondary structure in this state mirrors that in the folded state and that domain swapping is not limited to the folded states of proteins. Although the interface between cystatin-fold units is poorly defined for cystatin A, the dimers are the appropriate size to account for the electron-dense regions in amyloid protofilaments.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11532941}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11532941 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11532941}}
==About this Structure==
==About this Structure==
-
1N9J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N9J OCA].
+
1N9J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N9J OCA].
==Reference==
==Reference==
Line 35: Line 39:
[[Category: Stefin some]]
[[Category: Stefin some]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 25 04:51:19 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:37:13 2008''

Revision as of 11:37, 29 July 2008

Image:1n9j.png

Template:STRUCTURE 1n9j

Solution Structure of the 3D domain swapped dimer of Stefin A

Template:ABSTRACT PUBMED 11532941

About this Structure

1N9J is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Three-dimensional domain swapping in the folded and molten-globule states of cystatins, an amyloid-forming structural superfamily., Staniforth RA, Giannini S, Higgins LD, Conroy MJ, Hounslow AM, Jerala R, Craven CJ, Waltho JP, EMBO J. 2001 Sep 3;20(17):4774-81. PMID:11532941

Page seeded by OCA on Tue Jul 29 14:37:13 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1n9j"
Personal tools