1dec
From Proteopedia
(New page: 200px<br /><applet load="1dec" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dec" /> '''STRUCTURE OF THE RGD PROTEIN DECORSIN: CONSE...) |
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| - | [[Image:1dec.gif|left|200px]]<br /><applet load="1dec" size=" | + | [[Image:1dec.gif|left|200px]]<br /><applet load="1dec" size="350" color="white" frame="true" align="right" spinBox="true" |
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'''STRUCTURE OF THE RGD PROTEIN DECORSIN: CONSERVED MOTIF AND DISTINCT FUNCTION IN LEECH PROTEINS THAT AFFECT BLOOD CLOTTING'''<br /> | '''STRUCTURE OF THE RGD PROTEIN DECORSIN: CONSERVED MOTIF AND DISTINCT FUNCTION IN LEECH PROTEINS THAT AFFECT BLOOD CLOTTING'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The structure of the leech protein decorsin, a potent 39-residue | + | The structure of the leech protein decorsin, a potent 39-residue antagonist of glycoprotein IIb-IIIa and inhibitor of platelet aggregation, was determined by nuclear magnetic resonance. In contrast to other disintegrins, the Arg-Gly-Asp (RGD)-containing region of decorsin is well defined. The three-dimensional structure of decorsin is similar to that of hirudin, an anticoagulant leech protein that potently inhibits thrombin. Amino acid sequence comparisons suggest that ornatin, another glycoprotein IIb-IIIa antagonist, and antistasin, a potent Factor Xa inhibitor and anticoagulant found in leeches, share the same structural motif. Although decorsin, hirudin, and antistasin all affect the blood clotting process and appear similar in structure, their mechanisms of action and epitopes important for binding to their respective targets are distinct. |
==About this Structure== | ==About this Structure== | ||
| - | 1DEC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Macrobdella_decora Macrobdella decora]. Full crystallographic information is available from [http:// | + | 1DEC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Macrobdella_decora Macrobdella decora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DEC OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Macrobdella decora]] | [[Category: Macrobdella decora]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Krezel, A | + | [[Category: Krezel, A M.]] |
| - | [[Category: Lazarus, R | + | [[Category: Lazarus, R A.]] |
[[Category: Seymour-Ulmer, J.]] | [[Category: Seymour-Ulmer, J.]] | ||
[[Category: Wagner, G.]] | [[Category: Wagner, G.]] | ||
[[Category: blood coagulation]] | [[Category: blood coagulation]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:15:46 2008'' |
Revision as of 10:15, 21 February 2008
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STRUCTURE OF THE RGD PROTEIN DECORSIN: CONSERVED MOTIF AND DISTINCT FUNCTION IN LEECH PROTEINS THAT AFFECT BLOOD CLOTTING
Overview
The structure of the leech protein decorsin, a potent 39-residue antagonist of glycoprotein IIb-IIIa and inhibitor of platelet aggregation, was determined by nuclear magnetic resonance. In contrast to other disintegrins, the Arg-Gly-Asp (RGD)-containing region of decorsin is well defined. The three-dimensional structure of decorsin is similar to that of hirudin, an anticoagulant leech protein that potently inhibits thrombin. Amino acid sequence comparisons suggest that ornatin, another glycoprotein IIb-IIIa antagonist, and antistasin, a potent Factor Xa inhibitor and anticoagulant found in leeches, share the same structural motif. Although decorsin, hirudin, and antistasin all affect the blood clotting process and appear similar in structure, their mechanisms of action and epitopes important for binding to their respective targets are distinct.
About this Structure
1DEC is a Single protein structure of sequence from Macrobdella decora. Full crystallographic information is available from OCA.
Reference
Structure of the RGD protein decorsin: conserved motif and distinct function in leech proteins that affect blood clotting., Krezel AM, Wagner G, Seymour-Ulmer J, Lazarus RA, Science. 1994 Jun 24;264(5167):1944-7. PMID:8009227
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